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In this multicenter study, 2D spatial mapping of J-coupled resonances at 3T and 4T was performed using short-TE (15 ms) proton echo-planar spectroscopic imaging (PEPSI). Water-suppressed (WS) data were acquired in 8.5 min with 1-cm(3) spatial resolution from a supraventricular axial slice. Optimized outer volume suppression (OVS) enabled mapping in close(More)
Improved detection of J-coupled neurometabolites through the use of modified proton magnetic resonance spectroscopy (1H-MRS) techniques has recently been reported. TE-averaged point-resolved spectroscopy (PRESS) uses the J modulation effects by averaging FIDs with differing echo times to improve detection of glutamate, while standard PRESS detection of(More)
The resting state amplitude of low frequency fluctuations (ALFF) in functional magnetic resonance imaging has been shown to be reliable in healthy subjects, and to correlate with antipsychotic treatment response in antipsychotic-naïve schizophrenia patients. We found moderate to high test-retest stability of ALFF in chronically treated schizophrenia(More)
BACKGROUND Cognitive deficits in schizophrenia may be related to glutamatergic dysfunction, but in vivo measurement of glutamate metabolism has been challenging. We examined the relationship between glutamate metabolism and cognitive function in schizophrenia. METHODS Thirty subjects with DSM-IV schizophrenia and 28 healthy volunteers were studied using 4(More)
IMPORTANCE The N-methyl-d-aspartic acid receptor hypofunction model of schizophrenia predicts a paradoxical increase in synaptic glutamate release. In vivo measurement of glutamatergic neurotransmission in humans is challenging, but glutamine, the principal metabolite of synaptic glutamate, can be quantified with proton magnetic resonance spectroscopy(More)
A 1H magnetic resonance spectroscopic imaging study at 3T and short echo time was conducted to evaluate both the reproducibility, as measured by the interscan coefficient of variation (CV), and test-retest reliability, as measured by the intraclass correlation coefficient (ICC), of measurements of glutamate (Glu), combined glutamate and glutamine (Glx),(More)
White matter disruption has been repeatedly documented in schizophrenia consistent with microstructural disorganization (reduced fractional anisotropy (FA)) and axonal dysfunction (reduced N-acetylaspartate NAAc). However, the clinical significance of these abnormalities is poorly understood. Diffusion tensor and proton spectroscopic imaging where used to(More)
The neurobiology of schizophrenia (SZ) may be altered in older versus younger adults with SZ, as less frequent episodes of symptom exacerbation and increased sensitivity to medications are observed in older age. The goal of this study was to examine the effect of age and diagnosis on glutamate and cerebral blood flow (rCBF) in adults with SZ and healthy(More)
The title coordination polymer, [Zn(C6H4NO3)2] n , was prepared under hydro-thermal conditions by the reaction of zinc nitrate with 5-hy-droxy-nicotinic acid in the presence of malonic acid. In the structure, the Zn(II) ion is coordinated by two carboxyl-ate O atoms and two pyridine N atoms of four 5-hy-droxy-nicotinate ligands in a distorted tetra-hedral(More)
In the title compound, [Eu2(C6H5NO3)2(C2O4)3(H2O)4] n , the Eu(III) atom is bonded to one O atom from a monodentate 5-hy-droxy-pyridin-1-ium-3-carboxyl-ate ligand, six O atoms from three oxalate ligands and two water mol-ecules, exhibiting a highly distorted tricapped trigonal geometry. Three independent oxalate ligands, each lying on an inversion center,(More)