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New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and(More)
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest(More)
We present in this paper a novel nonlinear model predictive control scheme that guarantees asymptotic c1osed-loop stability. The scheme can be applied to both stable and unstable systems with input constraints. The objective functional to be minimized consists of an integral square error (ISE) part over a finite time horizon plus a quadratic terminal cost.(More)
Forensic dentistry involves the identiÿcation of people based on their dental records, mainly available as radiograph images. Our goal is to automate this process using image processing and pattern recognition techniques. Given a postmortem radiograph, we search a database of antemortem radiographs in order to retrieve the closest match with respect to some(More)
The brown planthopper (BPH) is the most destructive pest of rice (Oryza sativa) and a substantial threat to rice production, causing losses of billions of dollars annually1,2. Breeding of resistant cultivars is currently hampered by the rapid breakdown of BPH resistance2. Thus, there is an urgent need to identify more effective BPH-resistance genes. Here,(More)
Lead (Pb) in individual aerosol particles was measured using single particle aerosol mass spectrometer (ATOFMS) in the summer of 2007 in Shanghai, China. Pb was found in 3% of particles with diameters in the range 0.1-2.0 microm. Single particle data were analyzed focusing on the particles with high Pb content which were mostly submicron. Using the ART-2a(More)
The purpose of this paper is to investigate neural network capability systematically. The main results are: 1) every Tauber-Wiener function is qualified as an activation function in the hidden layer of a three-layered neural network; 2) for a continuous function in S'(R(1 )) to be a Tauber-Wiener function, the necessary and sufficient condition is that it(More)
With the growing adoption of Role-Based Access Control (RBAC) in commercial security and identity management products, how to facilitate the process of migrating a non-RBAC system to an RBAC system has become a problem with significant business impact. Researchers have proposed to use data mining techniques to discover roles to complement the costly(More)