Holly J. Frank

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To maximize disease control, patients must participate effectively in their medical care. The authors developed an intervention designed to increase the involvement of patients in medical decision making. In a 20-minute session just before the regular visit to a physician, a clinic assistant reviewed the medical record of each experimental patient with(More)
Isolated brain capillaries were used as a model system to test for binding and internalization of insulin and insulin-like growth factors (IGF) I and II. At 37 degrees C, the maximum specific binding of the 125I-labeled peptides was 48.0 +/- 0.8%/mg capillary protein for IGF I, 40.6 +/- 1.4% for IGF II, and 15.1 +/- 0.6% for insulin. The concentration of(More)
1. No evidence has been reported to date which indicates that peptides such as insulin, the enkephalins, or TRH traverse the BBB by specific transport systems. Therefore, the use of latentiated (lipid-soluble) derivatives of peptides provides the most practical approach to circumvent the restricted permeability of the BBB to peptides. In contrast to the(More)
Telemetry has allowed researchers to document the upstream migrations of anadromous fish in freshwater. In many anadromous alosine telemetry studies, researchers use downstream movements (“fallback”) as a behavioral field bioassay for adverse tag effects. However, these downstream movements have not been uniformly reported or interpreted. We quantified(More)
—Anadromous river herring (alewives Alosa pseudoharengus and blueback herring A. aestivalis), which constitute a historically and ecologically important component of coastal rivers, have declined precipitously throughout the Atlantic seaboard. Suggested causes of river herring decline include commercial fishing and predation by striped bass Morone(More)
The blood-brain barrier separates brain interstitial space from blood and is formed by brain capillary endothelial cells that are fused together by epithelial-like tight junctions. Study of the blood-brain barrier traditionally has been a relatively arcane field, even for neurobiologists. However, advances over the last 10 years in understanding the(More)
Recent in vivo autoradiographic studies have suggested that circulating insulin may bind to the capillary wall, i.e., the blood-brain barrier. In the present study the blood-brain barrier insulin receptor was examined directly by measuring [125I]-iodoinsulin binding to capillaries isolated from fresh bovine cerebral cortex. Microvessels were prepared by(More)
Thyroid hormones and insulin regulate numerous cell processes and potentially interact through the transcriptional regulation of key genes. For instance, thyroid hormones stimulate the transcription of the fatty acid synthase and malic enzyme genes in chick embryonic hepatocytes, while insulin amplifies these effects. It is possible that insulin augments(More)
An in vitro model system employing cultured, adult, bovine aortic endothelial cells was used to study the mechanism of insulin stimulation of aminoisobutyric acid (AIB) uptake and the effects of low-density lipoprotein (LDL), malondialdehyde-altered LDL (MDA-LDL), and B-migrating very-low-density lipoprotein (B-VLDL) on this process. The insulin response(More)