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  • Holly Heaslet, Bailin Shaw, Anil T. Mistry, Alita A Miller
  • Biology, Medicine
  • Journal of structural biology
  • 2009 (First Publication: 1 August 2009)
  • Bacterial cell wall transglycosylases (TGs) and transpeptidases (TPs) are ideal drug targets due to their essentiality, accessibility and lack of mammalian homologs. Although antibacterial therapyContinue Reading
  • Holly Heaslet, Melissa Harris, +6 authors J Richard Miller
  • Chemistry, Medicine
  • Proteins
  • 2009 (First Publication: 15 August 2009)
  • Dihydrofolate reductase (DHFR) is the enzyme responsible for the NADPH-dependent reduction of 5,6-dihydrofolate to 5,6,7,8-tetrahydrofolate, an essential cofactor in the synthesis of purines,Continue Reading
  • Holly Heaslet, William E. Royer
  • Chemistry, Medicine
  • Structure
  • 1999 (First Publication: 1 May 1999)
  • BACKGROUND The hemoglobins of the sea lamprey are unusual in that cooperativity and sensitivity to pH arise from an equilibrium between a high-affinity monomer and a low-affinity oligomer. AlthoughContinue Reading
  • Artem G Evdokimov, Marlene J Mekel, +22 authors Jia Liu
  • Biology, Medicine
  • Journal of structural biology
  • 2008 (First Publication: 1 April 2008)
  • In this article, we describe for the first time the high-resolution crystal structure of a phenylalanine tRNA synthetase from the pathogenic bacterium Staphylococcus haemolyticus. We demonstrate theContinue Reading
  • Michael J. Giffin, Holly Heaslet, +7 authors Bruce E. Torbett
  • Medicine, Chemistry
  • Journal of medicinal chemistry
  • 2008 (First Publication: 23 October 2008)
  • Treatment with HIV-1 protease inhibitors, a component of highly active antiretroviral therapy (HAART), often results in viral resistance. Structural and biochemical characterization of a 6X proteaseContinue Reading