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- Darin R. Rokyta, Christina L Burch, S. Brian Caudle, Holly A. Wichman
- Journal of bacteriology
- 2006
Bacteriophage genomic evolution has been largely characterized by rampant, promiscuous horizontal gene transfer involving both homologous and nonhomologous source DNA. This pattern has emerged… (More)
- J. J. Bull, Marty R Badgett, +5 authors Ian J. Molineux
- Genetics
- 1997
Replicate lineages of the bacteriophage phiX 174 adapted to growth at high temperature on either of two hosts exhibited high rates of identical, independent substitutions. Typically, a dozen or more… (More)
- Darin R. Rokyta, Paul Joyce, S. Brian Caudle, Holly A. Wichman
- Nature Genetics
- 2005
The primary impediment to formulating a general theory for adaptive evolution has been the unknown distribution of fitness effects for new beneficial mutations. By applying extreme value theory,… (More)
- James J. Bull, Marty R Badgett, Holly A. Wichman
- Molecular biology and evolution
- 2000
High temperature inhibits the growth of the wild-type bacteriophage phiX174. Three different point mutations were identified that each recovered growth at high temperature. Two affected the major… (More)
- Holly A. Wichman, Marty R Badgett, Leslie A. Scott, Carla Boulianne, J. J. Bull
- Science
- 1999
The molecular basis of adaptation is a major focus of evolutionary biology, yet the dynamic process of adaptation has been explored only piecemeal. Experimental evolution of two bacteriophage lines… (More)
- Wayne D. Crill, Holly A. Wichman, J. J. Bull
- Genetics
- 2000
Experimental adaptation of the bacteriophage phiX174 to a Salmonella host depressed its ability to grow on the traditional Escherichia host, whereas adaptation to Escherichia did not appreciably… (More)
- Holly A. Wichman, Leslie A. Scott, Clark Yarber, J. J. Bull
- Philosophical transactions of the Royal Society…
- 2000
Genomes of the closely related bacteriophages phiX174 and S13 are 5386 bases long and differ at 114 nucleotides, affecting 28 amino acids. Both parental phages were adapted to laboratory culture… (More)
- Michael A. Cantrell, L Scott, Celeste J. Brown, Armando R Martinez, Holly A. Wichman
- Genetics
- 2008
LINE-1 (L1) retrotransposons are the most abundant type of mammalian retroelement. They have profound effects on genome plasticity and have been proposed to fulfill essential host functions, yet it… (More)
- Craig J. Beisel, Darin R. Rokyta, Holly A. Wichman, Paul Joyce
- Genetics
- 2007
In modeling evolutionary genetics, it is often assumed that mutational effects are assigned according to a continuous probability distribution, and multiple distributions have been used with varying… (More)
L1s (LINE-1: Long Interspersed Nuclear Element 1) are present in all mammals examined to date. They occur in both placental mammals and marsupials and thus are thought to have been present in the… (More)