Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Different trajectories of parallel evolution during viral adaptation.

• Holly A. Wichman, Marty R Badgett, L A Scott, Carla Boulianne, J J Bull
• Science
• 1999

The molecular basis of adaptation is a major focus of evolutionary biology, yet the dynamic process of adaptation has been explored only piecemeal. Experimental evolution of two bacteriophage lines… (More)

Exceptional convergent evolution in a virus.

• J. J. Bull, Marty R Badgett, +5 authors Ian J. Molineux
• Genetics
• 1997

Replicate lineages of the bacteriophage phiX 174 adapted to growth at high temperature on either of two hosts exhibited high rates of identical, independent substitutions. Typically, a dozen or more… (More)

Horizontal gene transfer and the evolution of microvirid coliphage genomes.

• Darin R Rokyta, Christina L Burch, S. Brian Caudle, Holly A. Wichman
• Journal of bacteriology
• 2006

Bacteriophage genomic evolution has been largely characterized by rampant, promiscuous horizontal gene transfer involving both homologous and nonhomologous source DNA. This pattern has emerged… (More)

Evolutionary reversals during viral adaptation to alternating hosts.

• Wayne D. Crill, Holly A. Wichman, J J Bull
• Genetics
• 2000

Experimental adaptation of the bacteriophage phiX174 to a Salmonella host depressed its ability to grow on the traditional Escherichia host, whereas adaptation to Escherichia did not appreciably… (More)

Evolutionary feedback mediated through population density, illustrated with viruses in chemostats.

• J. J. Bull, Jack H. Millstein, Jason Orcutt, Holly A. Wichman
• The American naturalist
• 2006

A cornerstone of evolutionary ecology is that population density affects adaptation: r and K selection is the obvious example. The reverse is also appreciated: adaptation impacts population density.… (More)

Big-benefit mutations in a bacteriophage inhibited with heat.

• J. J. Bull, Marty R Badgett, Holly A. Wichman
• Molecular biology and evolution
• 2000

High temperature inhibits the growth of the wild-type bacteriophage phiX174. Three different point mutations were identified that each recovered growth at high temperature. Two affected the major… (More)

Testing the extreme value domain of attraction for distributions of beneficial fitness effects.

• Craig J. Beisel, Darin R Rokyta, Holly A. Wichman, Paul Joyce
• Genetics
• 2007

In modeling evolutionary genetics, it is often assumed that mutational effects are assigned according to a continuous probability distribution, and multiple distributions have been used with varying… (More)

An empirical test of the mutational landscape model of adaptation using a single-stranded DNA virus

• Darin R Rokyta, Paul Joyce, S. Brian Caudle, Holly A. Wichman
• Nature Genetics
• 2005

The primary impediment to formulating a general theory for adaptive evolution has been the unknown distribution of fitness effects for new beneficial mutations. By applying extreme value theory,… (More)

Loss of LINE-1 activity in the megabats.

• Michael A. Cantrell, L A Scott, Celeste J. Brown, Armando R Martinez, Holly A. Wichman
• Genetics
• 2008

LINE-1 (L1) retrotransposons are the most abundant type of mammalian retroelement. They have profound effects on genome plasticity and have been proposed to fulfill essential host functions, yet it… (More)

Mutational effects and population dynamics during viral adaptation challenge current models.

• Craig R. Miller, Paul Joyce, Holly A. Wichman
• Genetics
• 2011

Adaptation in haploid organisms has been extensively modeled but little tested. Using a microvirid bacteriophage (ID11), we conducted serial passage adaptations at two bottleneck sizes (10(4) and… (More)

• ‹
• 1
• 2
• 3
• 4
• 5
• ›