Holger Spangenberger

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Tetanus-induced long-term potentiation (LTP) of population action potentials at 22 degrees C was investigated in area CA1 of hippocampal slices prepared from hibernating (HH) and warm-acclimated Turkish hamsters (WH) and rats. LTP elicited at this temperature was significantly stronger in HH slices compared to WH and rat slices. Hibernation-related(More)
The effects of adenosine on synaptic transmission were studied with extracellular recordings of stimulus-induced population action potentials in area CA1 of hippocampal slices prepared from hibernating (HH) and warm-acclimated Turkish hamsters (WH) and rats. In HH as well as WH and rat slices, adenosine generally reduced the population spike amplitude and(More)
BACKGROUND Hydroxyurea (HU) is a good-controllable and well-tolerated cytostatic drug. CASE REPORT Two patients with a myeloproliferative disease, who suffered from fever, lung symptoms and reticulonodular infiltrates on both sides after 4 and 10 weeks of HU medication, are introduced. One patient additionally presented with multiple, 1-cm diameter,(More)
The effects of histamine on synaptic transmission were studied at 37 degrees C and 22 degrees C with extracellular recordings of stimulus-induced population action potentials in area CA1 of hippocampal slices prepared from hibernating (HTH) and warm-acclimated Turkish hamsters (WTH) and rats. In rat slices, application of 50 microM histamine had no effects(More)
BACKGROUND Acanthosis nigricans (AN) comprises a broad spectrum of etiologic subtypes. The underlying pathomechanisms have not yet been completely clarified. We present a patient affected with a syndromelike AN subtype including disturbed epidermopoiesis as evidenced by immunohistologic findings and in situ hybridization. OBSERVATIONS A 54-year-old white(More)
Hintergrund: Hydroxyurea (HU) ist ein gut steuerbares und sehr nebenwirkungsarmes Zytostatikum. Fallbeschreibung: Vorgestellt werden die Krankheitsbilder zweier Patienten mit einer chronischen myeloproliferativen Erkrankung, die nach 4- und 10-wöchiger HU-Therapie hohes Fieber, Lungensymptome und retikulonoduläre Infiltrate beidseits entwickelten. Ein(More)
Ein 76-jähriger Patient wurde mit Hepatosplenomegalie, Anämie, Thrombopenie, Eosinophilie, Erhöhung der Laktatdehydrogenase und erythroleukämischem Blutbild stationär aufgenommen. Die Knochenmarkhistologie, die Immunhistologie und der molekulargenetische Nachweis der c-kit-Mutation D816 V belegten eine systemische Mastozytose. Eine auswärts vermutete(More)
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