Holger Hövel

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CONTEXT IGF-I and IGF binding protein-3 (IGFBP-3) are essential for growth and maturation of the developing brain. OBJECTIVE The aim of this study was to evaluate the association between postnatal serum concentrations of IGF-I and IGFBP-3 and brain volumes at term in very preterm infants. DESIGN Fifty-one infants with a mean (sd) gestational age (GA) of(More)
BACKGROUND To evaluate the relationships between postnatal change in circulatory insulin-like growth factor-I (IGF-I) concentrations, brain volumes, and developmental outcome at 2 y of age in very preterm infants. METHODS IGF-I was measured weekly, and nutritional intake was calculated daily from birth until a postmenstrual age (PMA) of 35 wk. Individual(More)
OBJECTIVE To assess auditory event-related potentials at preschool age in children born very preterm (VP, 27.4 ± 1.9 gestational weeks, n=70) with a high risk of cognitive dysfunction. METHODS We used an oddball paradigm consisting of a standard tone randomly replaced by one of three infrequent deviants (differing in frequency, sound direction or(More)
BACKGROUND Auditory event-related potentials (AERP) are neurophysiological correlates of sound perception and cognitive processes. Our aim was to study in very preterm born children at preschool age if AERP correlate with cognitive outcome. METHODS Seventy children (mean ± SD gestational age 27.4 ± 1.9 wk, birth weight 996 ± 288 g) were investigated at(More)
According to the valid requirements, samples of WI-38 cells taken prior to the final subcultivation for vaccine production by the manufacturer, were reconstituted, subcultivated and investigated in our control laboratories. Chromosome monitoring was done using permanent orcein stained slide preparations for direct evaluation and photographs of all selected(More)