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To provide a novel, robust algorithm for classification of lung tissue depicted by multi-detector computed tomography (MDCT) based on the topology of CT-attenuation values and to compare discriminative results with densitometric methods. Two hundred seventy-five cubic volumes of interest (VOI, edge length 40 pixels) were obtained from MDCT chest CT(More)
UNLABELLED In this experimental study, we evaluated the reproducibility error of mechanical strength tests of the proximal femur when simulating a fall on the trochanter. Based on side differences in femoral failure loads in 55 pairs of femora, we estimated the upper limit of the precision error to be 15% for the side impact test, whereas the intersubject(More)
PURPOSE To retrospectively assess an improved quantitative methodology with separate assessment of perfusion and permeability for characterization of primary renal cell carcinoma (RCC) and monitoring antiangiogenic treatment. MATERIALS AND METHODS Fifteen RCC patients before surgery, 6 RCC patients before and after neoadjuvant antiangiogenic therapy, and(More)
RATIONALE AND OBJECTIVES A novel, nonlinear morphologic measure [DeltaP(alpha)] based on local 3D scaling properties was applied to high-resolution magnetic resonance images (HR-MRI) of human trabecular bone to predict biomechanical strength in vitro. METHODS We extracted DeltaP(alpha) and traditional morphologic parameters (apparent trabecular volume(More)
UNLABELLED We introduce an algorithm to evaluate hip DXA scans using quantitative image analysis procedures based on the Minkowski functionals (MF) for differentiation between post-menopausal women with and without hip fracture. In a population of 30 post-menopausal women, the new parameter has a highly discriminative potential with a performance superior(More)
INTRODUCTION The purpose of this study was to obtain different structure measures as the three-dimensional (3D)-based scaling index method (SIM) and standard two-dimensional (2D) bone histomorphometric parameters from high-resolution (HR) magnetic resonance (MR) images of the distal radius and to compare these parameters with bone mineral density (BMD) in(More)
Sleep disordered breathing with or without nocturnal hypercapnic hypoventilation is a common complication of respiratory muscle weakness in childhood neuromuscular disorders. Nocturnal hypercapnic hypoventilation as a sign of respiratory muscle fatigue, portends a particularly poor prognosis. We aimed at identifying daytime predictors of sleep disordered(More)
OBJECTIVE To evaluate scanner-generated images of hip specimens obtained from dual energy X-ray absorptiometry (DXA) by quantitative image analysis of bone mineral distribution in the standard regions of interest (ROI), to predict the ultimate mechanical strength, and to compare the predictive potential with standard densitometry. MATERIALS AND METHODS(More)
The purpose of this study was to establish and evaluate contrast-enhanced MR-lymphangiography (MRL) at 3.0 T for detection and visualization of abnormalities of the peripheral lymphatic system. Sixteen patients were examined with a highly resolved isotropic T1w-3D-GRE-(FLASH) sequence (TR 3.76 ms/TE 1.45 ms/FA 30 degrees /voxel-size 0.8 x 0.8 x 0.8 mm(3))(More)
OBJECTIVE We used an algorithm for quantitative image processing to classify breast tissue into the categories fibrosis, involution atrophy, and normal. The algorithm entailed use of Minkowski functionals in topologic analysis of x-ray attenuation patterns on digital mammograms. The results were compared with those of techniques based on evaluation of(More)