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Features of Idebenone and Related Short-Chain Quinones that Rescue ATP Levels under Conditions of Impaired Mitochondrial Complex I
Short-chain quinones have been investigated as therapeutic molecules due to their ability to modulate cellular redox reactions, mitochondrial electron transfer and oxidative stress, which areExpand
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The HERA-B Collaboration
Inclusive doubly differential cross sections d2σpA/dxF dp 2 T as a function of Feynman-x (xF ) and transverse momentum (pT ) for the production of K 0 S, Λ and Λ̄ in proton-nucleus interactions atExpand
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The orally active melanocortin-4 receptor antagonist BL-6020/979: a promising candidate for the treatment of cancer cachexia
BackgroundUnder physiological conditions, the melanocortin system is a crucial part of the complex network regulating food intake and energy expenditure. In pathological states, like cachexia, theseExpand
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Hyphenation of capillary high-performance liquid chromatography with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for nano-scale screening of single-bead combinatorial
This paper focuses on the technical aspects of chemical screening from 384-well plate nano-scale single-bead combinatorial libraries. The analytical technique utilized is a combination of capillaryExpand
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Discovery of beta-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV.
Modifications of DPP-4 inhibitor 5, that was discovered by structure based design, are described and structure-activity relationships discussed. With analogue 7k one of the most potent non-covalentExpand
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Synthesis and Quality Control of Thiol Tagged Compound Libraries for Chemical Microarrays
A method for the synthesis and quality control of compound collections containing reactive thiol functions was developed. Such libraries form the basis for the construction of chemical microarrays toExpand
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Production of the charmonium states χc1 and χc2 in proton nucleus interactions at √s = 41.6 GeV
A measurement of the ratio R xc = (Χ c → J/ψ + γ)/J/ψ in pC, pTi, and pW interactions at 920 GeV/c (s = 41.6 GeV) in the Feynman-x range -0.35 < x J/ψ F < 0.15 is presented. Both μ + μ - and e + e -Expand
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Solid-phase synthesis of 3-aryl-3-oxo-propan amides by reaction of lithium enolates with 4-nitrophenyl carbamate resin or polymer-bound isocyanate
Two synthetic procedures to enable a straightforward and efficient solid-phase synthesis of 3-aryl-3-oxo-propan amides (β-keto amides) are described and compared. Lithium enolates, which can beExpand
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New specific immunophilin ligands as anti-asthmatics, anti-allergic agents, anti-inflammatory drugs, immunosuppressants, anti-psoriasis, neuroprotective
New specific immunophilin ligands of general formula (I) have anti-asthmatic, anti-allergic, anti-rheumatic, anti-inflammatory, immunosuppressive, anti-psoriatic and neuroprotective effects and areExpand