Holger Christiansen

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  • Alexander Schramm, Johannes H Schulte, Ludger Klein-Hitpass, Werner Havers, Hauke Sieverts, Bernd Berwanger +6 others
  • 2005
Neuroblastoma is a common childhood tumor comprising cases with rapid disease progression as well as spontaneous regression. Although numerous prognostic factors have been identified, risk evaluation in individual patients remains difficult. To define a reliable prognostic predictor and gene signatures characteristic of biological subgroups, we performed(More)
  • Katrin Nowak, Kornelius Kerl, Daniel Fehr, Christoph Kramps, Christine Gessner, Katrin Killmer +4 others
  • 2006
The oncogene BMI1 encodes a polycomb group transcription factor that is required for embryonic development and self-renewal of stem cells. Despite these important functions little is known about the regulation of BMI1 expression. A cDNA microarray based search for target genes of E2F-1 in neuroblastoma cells expressing a 4-OHT-regulated E2F-1-ER fusion(More)
Tumor stage, age of patient, and amplification of MYCN predict disease outcome in neuroblastoma. To gain insight into the underlying molecular pathways, we have obtained expression profiles from 94 primary neuroblastoma specimens. Advanced tumor stages show a characteristic expression profile that includes downregulation of multiple genes involved in signal(More)
There are several different algorithms published for the identification of differentially expressed genes in DNA microarray experiments. Such algorithms produce ordered lists of genes. To compare the performance of these algorithms established measurements from Information Retrieval are proposed. A benchmark data set with known properties is generated and(More)
The amplification of putative oncogenes is a common finding within the genome of various cancer types. Identification and further targeting of specific junction sites within the sequence of genomic amplicons (amplicon fusion sites, AFS) by PCR (AFS-PCR) is suitable for quantification of minimal residual disease (MRD). This approach has recently been(More)
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