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We have previously found that monkey V␥2V␦2 ؉ T cells mount adaptive immune responses in response to Mycobacterium bovis bacillus Calmette-Guérin infections. We have now analyzed rhesus monkey ␥␦ T cell responses to nonpeptide Ags and superan-tigens. Like human V␥2V␦2 ؉ T cells, rhesus monkey ␥␦ T cells are stimulated when exposed to prenyl pyrophosphate,(More)
The specificity of immunoglobulins and ␣ / ␤ T cell receptors (TCRs) provides a framework for the molecular basis of antigen recognition. Yet, evolution has preserved a separate lineage of ␥ / ␦ antigen receptors that share characteristics of both immunoglobulins and ␣ / ␤ TCRs but whose antigens remain poorly understood. We now show that T cells of the(More)
Human Vg2Vd2 T cells are stimulated by prenyl pyrophosphates, such as isopentenyl pyrophosphate (IPP), and play important roles in mediating immunity against microbial pathogens and have potent anti-tumor activity. (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) has been identified as a metabolite in the 2-C-methyl-D-erythritol-4 phosphate (MEP)(More)
The specificity of immunoglobulins and ␣ / ␤ T cell receptors (TCRs) provides a framework for the molecular basis of antigen recognition. Yet, evolution has preserved a separate lineage of ␥ / ␦ antigen receptors that share characteristics of both immunoglobulins and ␣ / ␤ TCRs but whose antigens remain poorly understood. We now show that T cells of the(More)
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