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OBJECTIVE To determine adherence to and effectiveness of antiretroviral therapy (ART) in adolescents vs. adults in southern Africa. DESIGN Observational cohort study. SETTING Aid for AIDS, a private sector disease management program in southern Africa. SUBJECTS Adolescents (age 11-19 years; n = 154) and adults (n = 7622) initiating ART between 1999(More)
This study evaluated the effect of culture on the relationship between psychological dimensions underlying odor perception and odor categorization. In a first experiment, French, Vietnamese and American participants rated several perceptual dimensions of everyday odorants, and sorted these odorants on the basis of their similarity. Results showed that the(More)
BACKGROUND AND OBJECTIVES Preconditioning gas by humidification and warming the pneumoperitoneum improves laparoscopic outcomes. This prevents peritoneal desiccation and detrimental events related to traditional cold-dry gas. Few comparisons have been done comparing traditional cold-dry, heated-only, and humidified-warmed carbon dioxide. METHODS A(More)
BACKGROUND We aimed to measure the overlap between the social networks of injection drug users (IDUs) and the patterns of related hepatitis C virus (HCV) infections among IDUs. METHODS A cohort of 199 IDUs (138 of whom were HCV RNA positive) was recruited from a local drug scene in Melbourne, Australia, and was studied using social network analysis and(More)
BACKGROUND Antiretroviral therapy (ART) adherence predicts HIV disease progression and survival, but its effect on direct health care costs is unclear. OBJECTIVE To determine the effect of ART adherence on direct health care costs among adults in a resource-limited setting. DESIGN Cohort study. SETTING Aid for AIDS, a private-sector disease management(More)
BACKGROUND Currently, boosted protease inhibitor-containing regimens are the only option after first-line regimen failure available for patients in most resource-limited settings, yet little is known about long-term adherence and outcomes. METHODS We enrolled patients with virologic failure (VF) who initiated lopinavir/ritonavir-containing second-line(More)
OBJECTIVES The objectives of this study were to quantify mothers' perceptions of their children's sizes and explore mothers' views of child growth, diet, activity, and health. Photographs of children from the Berkeley Longitudinal Growth Study (on Centers for Disease Control and Prevention [CDC] Web site) were used to stimulate discussion with mothers about(More)
OBJECTIVE Generalized anxiety disorder is common among older adults and leads to diminished health and cognitive functioning. Although antidepressant medications are efficacious, many elderly individuals require augmentation treatment. Furthermore, little is known about maintenance strategies for older people. The authors examined whether sequenced(More)
OBJECTIVE Generalized anxiety disorder (GAD) is a prevalent psychiatric condition in older adults with deleterious effects on health and cognition. Although selective serotonin reuptake inhibitor (SSRI) medications have some efficacy as acute treatments for geriatric GAD, incomplete response is the most common outcome of monotherapy. We therefore developed(More)
One of the most critical challenges for today's and future data-intensive and big-data problems is data storage and analysis. This paper first highlights some challenges of the new born Big Data paradigm and shows that the increase of the data size has already surpassed the capabilities of today's computation architectures suffering from the limited(More)