Ho-Joong Kim

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Major goals within the development of nanomedicine for cancer therapy include enhancing therapeutic effi cacy, the selective targeting of cancerous cells and the ability to track drug import. [ 1 ] The advancement of next-generation nanocarriers as drug delivery platforms will require the incorporation of these useful properties, through which adverse side(More)
Temporarily implanted devices, such as drug-loaded contact lenses, are emerging as the preferred treatment method for ocular diseases like glaucoma. Localizing the delivery of glaucoma drugs, such as timolol maleate (TM), can minimize adverse effects caused by systemic administration. Although eye drops and drug-soaked lenses allow for local treatment,(More)
The purpose of this study is to investigate the change in biomechanical milieu following removal of pedicle screws in instrumented single level lumbar arthrodesis. Using a validated finite element (FE) model of the intact lumbar spine (L2-5), two scenarios of L3-4 lumbar fusion were simulated: posterolateral fusion (PLF) at L3-4 using pedicle screws (PLF(More)
The purpose of this study was to translate pain sensitivity questionnaires (PSQ) into the Korean language, perform a cross-cultural adaption of the PSQ, and validate the Korean version of PSQ in patients with degenerative spinal disease. The PSQ was translated forward and backward, cross-culturally adapted by 2 independent translators, and approved by an(More)
Few studies have shown the relationship between the curve pattern and nerve root symptoms in degenerative lumbar scoliosis, and its mechanism remains unclear. We developed a finite element model of two patterns of scoliotic curves (isolated lateral bending curve, lateral bending combined with rotation curve). The stress on the nerve root was calculated on(More)
BACKGROUND The osteoporosis and lumbar canal stenosis, in elderly patients are under diagnosed and under reported. We report a cross sectional study to demonstrate the osteoporotic profile in patients with lumbar spinal stenosis (LSS) and to determine the proportion of patients with LSS who need to be treated for osteoporosis. MATERIALS AND METHODS One(More)
We report here on an unusual case of multiple levels of asymmetric lumbar spondylolysis in a 19-year-old woman. The patient had severe low back pain of increasing intensity with lumbar instability, which was evident on the dynamic radiographs. MRI demonstrated the presence of abnormalities and the three dimensional CT scan revealed asymmetric complete(More)
PURPOSE The purpose of this study was to investigate the effects of unilateral pedicle screw fixation on the fusion segment and the superior adjacent segment after one segment lumbar fusion using validated finite element models. MATERIALS AND METHODS Four L3-4 fusion models were simulated according to the extent of decompression and the method of pedicle(More)
STUDY DESIGN Retrospective interventional study. PURPOSE To introduce a free-hand pedicle screw (PS) insertion technique without fluoroscopic guidance in the C7 vertebra and evaluate the procedure's feasibility and radiologic outcomes. OVERVIEW OF LITERATURE Although PS insertion at C7 has been recognized as a critical procedure in posterior cervical(More)
PURPOSE To investigate the difference in motion profiles between instrumented and non-instrumented fusion of the lumbar spine. METHOD In vivo retrospective radiological analysis of dynamic (flexion-extension) lateral plain films was performed in different lumbar spine fusion types. Twenty-eight patients underwent lumbar fusion surgery at the L4/5 level.(More)