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  • Hitomi Sawai, Norifumi Kawada, Katsutoshi Yoshizato, Hiroshi Nakajima, Shigetoshi Aono, Yoshitsugu Shiro
  • Chemistry, Medicine
  • Biochemistry
  • 2003 (First Publication: 1 May 2003)
  • Cytoglobin (Cgb) represents a fourth member of the globin superfamily in mammals, but its function is unknown. Site-directed mutagenesis, in which six histidine residues were replaced with alanine,Continue Reading
    The crystal structure of a truncated Aer2, a signal transducer protein from Pseudomonas aeruginosa, consisting of the heme-containing PAS and di-HAMP domains revealed that a distal tryptophan residueContinue Reading
  • Hitomi Sawai, Masaru Yamanaka, Hiroshi Sugimoto, Yoshitsugu Shiro, Shigetoshi Aono
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2012 (First Publication: 31 August 2012)
  • Although heme is a crucial element for many biological processes including respiration, heme homeostasis should be regulated strictly due to the cytotoxicity of free heme molecules. Numerous lacticContinue Reading