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Tissue-Restricted Expression of Nrf2 and Its Target Genes in Zebrafish with Gene-Specific Variations in the Induction Profiles
The results indicate the existence of gene-specific variations in the tissue specificity, which can be controlled by factors other than Nrf2. Expand
Nitro‐fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1‐Nrf2 system: a study using green fluorescent protein transgenic zebrafish
The results support the contention that OA‐NO2 and 15d‐PGJ2 share an analogous cysteine code as electrophiles and also have similar anti‐inflammatory roles. Expand
Genetic Evidence of an Evolutionarily Conserved Role for Nrf2 in the Protection against Oxidative Stress
Results reveal an evolutionarily conserved role of vertebrate Nrf2 in protection against oxidative stress, and there were no significant differences between wild-type and nrf2fh318 larvae with regard to their sensitivity to superoxide and singlet oxygen generators, suggesting that the importance of NRF2 in oxidative stress protection varies based on the type of reactive oxygen species (ROS). Expand
LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2
This study isolated and characterized a zebrafish mutant in histone Lys-specific demethylase 1 (LSD1/KDM1A), and found that LSD1 plays a role in the initiation of hematopoietic differentiation in the hemangioblast, a bipotent cell that can give rise to hematopolietic or endothelial progenitors. Expand
Sensory systems and ionocytes are targets for silver nanoparticle effects in fish
WISH in zebrafish embryos and larvae for a suite of genes involved with detoxifying processes and oxidative stress caused upregulation in the expression of mt2, gstp and gstm1 and down regulation of expression of both hmox1 and fth1 and there were both life stage and tissue-specific responses. Expand
Heme‐mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2‐dependent induction of zebrafish heme oxygenase 1
It is suggested that Bach1 regulates the liver specificity and transience of the Nrf2a‐dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue. Expand
Correction: Tissue-Restricted Expression of Nrf2 and Its Target Genes in Zebrafish with Gene-Specific Variations in the Induction Profiles
The Keap1-Nrf2 system serves as a defense mechanism against oxidative stress and electrophilic toxicants by inducing more than one hundred cytoprotective proteins, including antioxidants and phase 2Expand
Control of spacing between aminoalkyl functions by mesostructural transition in a polysilsesquioxane lamellar assembly
We synthesized lamellar solids by co-condensation of 3-(2-aminoethylamino)propyltriethoxysilane (AeAPTES) and tetraethyl orthosilicate (TEOS) in the presence of hexadecylsuccinic acid (C16SA) andExpand
[MRI-intracranial compliance analysis in patients with NPH].
This method makes it possible to non-invasively obtain a more detailed determination of the intracranial state and dynamics in NPH and to assist in its diagnosis. Expand
OLIVe: A Genetically Encoded Fluorescent Biosensor for Quantitative Imaging of Branched-Chain Amino Acid Levels inside Single Living Cells.
A Förster resonance energy transfer (FRET)-based genetically encoded bios sensor for BCAAs is developed, termed optical biosensor for leucine-isoleucines-valine (OLIVe), indicating that OLIVe can reliably report intracellular BCAA concentrations inside single living cells. Expand