Hitomi Kobayashi

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It is important to appropriately evaluate the driving performance of elderly persons. In the present study, near-infrared spectroscopy (NIRS) was employed to investigate differences of brain function between individuals with Alzheimer's disease (n=12) and healthy elderly controls (n=14) while they were being tested using a driving simulator. Changes of the(More)
INTRODUCTION The hypothalamic-pituitary-adrenal axis is known to be related to abdominal symptoms, and the relationship between abdominal pain and cortisol secretory patterns has been previously investigated using a cross-sectional approach. Here, we investigated the effect of day-to-day variations in salivary cortisol and dehydroepiandrosterone-sulfate(More)
INTRODUCTION Rheumatoid arthritis (RA) is a multi-organ inflammatory disorder associated with high cardiovascular morbidity and mortality. We sought to assess cardiac involvement using a comprehensive cardiac magnetic resonance imaging (cMRI) approach and to determine its association with disease characteristics in RA patients without symptomatic cardiac(More)
In this report we describe a patient with a clinical diagnosis of dementia with Lewy bodies, who had hallucinations of reading her thoughts in the air although she was alexic and unable to read. She also had severe visuoperceptual deficits and closing-in phenomenon. SPECT imaging demonstrated hypoperfusion of the left parieto-occipital cortices together(More)
Treatment with donepezil (maximum dose, 10 mg/day) was recently approved in Japan for severe Alzheimer's disease (AD). We examined the usefulness of serum insulin-like growth factor-I (IGF-I) level as a biomarker for predicting responders to 10 mg/day-donepezil treatment among mild-to-moderate AD patients. The study population consisted of 23(More)
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