Hitomi Hasegawa

Kazunari K. Yokoyama3
Chia-Chen Ku2
Ying-Chu Lin2
3Kazunari K. Yokoyama
2Chia-Chen Ku
2Ying-Chu Lin
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Transcription factor, Jun dimerization protein 2 (JDP2), binds directly to histones and DNAs and then inhibits the p300-mediated acetylation both of core histones and of reconstituted nucleosomes that contain JDP2 recognition DNA sequences. JDP2 plays a key role as a repressor of adipocyte differentiation by regulation of the expression of the gene C/EBPδ(More)
Activating transcription factor 2 (ATF2) and its homolog ATF7 are phosphorylated at Thr-69/Thr-71 and at Thr-51/Thr-53, respectively, by stress-activated MAPKs regulating their transcriptional functions in G1 and S phases. However, little is known about the role of ATF2 and ATF7 in G2/M phase. Here, we show that Cdk1-cyclin B1 phosphorylates ATF2 at(More)
  • Shyh-Shin Chiou, Sophie Sheng-Wen Wang, Deng-Chyang Wu, Ying-Chu Lin, Li-Pin Kao, Kung-Kai Kuo +17 others
  • 2013
We report here that the Jun dimerization protein 2 (JDP2) plays a critical role as a cofactor for the transcription factors nuclear factor-erythroid 2-related factor 2 (Nrf2) and MafK in the regulation of the antioxidants and production of reactive oxygen species (ROS). JDP2 associates with Nrf2 and MafK (Nrf2-MafK) to increase the transcription of(More)
During derivation of transgenic mouse strains with various TL and TL/H-2 chimeric genes, one strain, TgTle-3-1, introduced with a TL gene (Tla'-3), was found to have an abnormal thymic T cell population and to develop a high incidence of T cell lymphomas. To investigate the etiology of the thymic abnormalities and of the lymphomas, the development of(More)
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