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BACKGROUND/AIMS A 24-week, randomized, parallel-group, double-blind placebo-controlled study was conducted to evaluate the efficacy and tolerability of donepezil in severe Alzheimer's disease (AD). METHODS Patients with severe AD (Mini-Mental State Examination score 1-12; modified Hachinski Ischemic Score < or =6; Functional Assessment Staging > or =6)(More)
BACKGROUND/AIMS A 6-month, randomized, double-blind, placebo-controlled study was extended to evaluate long-term safety and efficacy of donepezil in community-dwelling Japanese patients with severe Alzheimer's disease (AD). METHODS 189 patients were enrolled from the double-blind study into a 52-week, open-label extension study. After a 2- to 8-week(More)
BACKGROUND AND AIMS The early detection and prevention of dementia is attracting attention. We therefore developed an easily performed protocol to identify patients with memory impairment which may progress to dementia, and evaluated its validity. METHODS We focused on short-term memory impairment alone, and named the test, consisting of 3 tasks, the(More)
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