Quantitative Proteomics Analysis of the Secretory Pathway
- A. Gilchrist, C. Au, J. Bergeron
- BiologyCell
- 15 December 2006
Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis.
- K. Hatsuzawa, Taku Tamura, I. Wada
- BiologyMolecular Biology of the Cell
- 1 September 2006
It is concluded that syntaxin 18 is involved in ER-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER and plasma or phagosomal membranes.
Regulated motion of glycoproteins revealed by direct visualization of a single cargo in the endoplasmic reticulum
- Hisao Nagaya, Taku Tamura, I. Wada
- BiologyJournal of Cell Biology
- 14 January 2008
It is proposed that diffusion of secretory glycoproteins in the ER lumen is controlled from the cytoplasm to reduce the chances of aggregation.
Involvement of a Novel Q-SNARE, D12, in Quality Control of the Endomembrane System*
- A. Okumura, K. Hatsuzawa, I. Wada
- BiologyJournal of Biological Chemistry
- 17 February 2006
It is suggested that D 12 participates in the degradative function of lysosomes, which is supported by evidence that D12 associates with VAMP7, a SNARE in the endosomal-lysosomal pathway.
Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains.
- Hisao Nagaya, I. Wada, YanâJun Jia, H. Kanoh
- BiologyMolecular Biology of the Cell
- 2002
DGKdelta negatively regulates ER-to-Golgi traffic by selectively inhibiting the formation of ER export sites without significantly affecting retrograde transport, indicating that the catalytic activity of DGK was not involved in the present observation.
Cancer stem cell markers in lung cancer
- Takeaki Miyata, T. Yoshimatsu, A. Gotoh
- Medicine, Biology
- 1 July 2015
Stepwise Assembly of Fibrinogen Is Assisted by the Endoplasmic Reticulum Lectin-Chaperone System in HepG2 Cells
- Taku Tamura, Seisuke Arai, Hisao Nagaya, J. Mizuguchi, I. Wada
- BiologyPLoS ONE
- 10 September 2013
This study shows that the maturation of fibrinogen, a hexameric secretory protein (two trimers from ι, β and γ subunits), occurs in a stepwise manner, providing a novel insight into the assembly of most abundant multi-subunit secretory proteins.
Piperazine-based Alpha-1 AR Blocker, Naftopidil, Selectively Suppresses Malignant Human Bladder Cells via Induction of Apoptosis.
- Yusuke Nakagawa, Hisao Nagaya, T. Miyata, Y. Wada, T. Oyama, A. Gotoh
- Biology, MedicineAnticancer Research
- 1 April 2016
It is concluded that naftopidil has potential as an antitumor drug against BCa in vitro and in vivo and provides a rationale for developing naftobidil in grade-independent treatment of BCa.
PTP1B Inhibition Causes Rac1 Activation by Enhancing Receptor Tyrosine Kinase Signaling
- A. Tsuchiya, T. Kanno, Hisao Nagaya, Tadashi Shimizu, A. Tanaka, T. Nishizaki
- Biology, ChemistryCellular Physiology and Biochemistry
- 1 April 2014
The results of the present study show that DCP-LA-induced PTP1B inhibition, possibly through its direct binding, causes Rac1 activation by enhancing a pathway along a receptor tyrosine kinase (RTK)/IRS-1/PI3K/Akt/Rac1 axis.
Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma
- Y. Kaku, Hisao Nagaya, T. Nishizaki
- Biology, MedicineCancer Science
- 21 May 2014
The results of the present study indicate that HUHS1015 could be developed as an effective anticancer drug for treatment of malignant pleural mesothelioma.
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