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The pathogenicity of influenza virus infection in the mice involves, at least in part, overreaction of the immune responses of the host rather than a direct effect of virus multiplication. Xanthine oxidase, which is responsible for the generation of oxygen free radicals, was elevated in serum and lung tissue of mice infected with influenza virus. To test(More)
Rapid eye movement sleep behavior disorder (RBD) is a parasomnia with clinical symptoms that include punching, kicking, yelling and leaping out of bed in sleep. Polysomnographic (PSG) finding showed REM sleep without muscle atonia. Clonazepam is generally used for treating RBD symptoms but melatonin was reported to be effective so we reconfirmed the effect(More)
We examined the effects of facial affect recognition on auditory ERP using facial drawings depicting sadness, no emotion, pleasure and anger. Auditory ERP were recorded using an oddball paradigm in 13 women and 13 men while pictures and test tones were presented. P300 peak amplitude, area, and latency, and also subject's reaction time, were evaluated. The(More)
Ten subjects were tested for eight sessions using an auditory oddball paradigm at 1-week and 1-month intervals to examine the stability of multiple event-related potential (ERP) components, in terms of trait (between session) and state (within session) reliability. The between session reliabilities presented as intraclass correlations (r') were 0.54 for the(More)
Stimulation of dopamine receptors may induce striatal Homer 1a, an immediate-early gene (IEG) that is involved in the molecular mechanism for the signaling pathway of the group I metabotropic glutamate receptors. This study examined the effects of the agonists for dopamine D(1)-like and D(2)-like receptors on gene expression of Homer 1a, in comparison with(More)
Extracellular recordings were obtained from neurons in the ventral tegmental area (VTA) of urethane-anesthetized rats. Neurons were divided into two types based on the latencies of antidromic activation following electrical stimulation of the nucleus accumbens (NAcc), and on the durations of action potentials. Type A neurons had longer latencies for(More)
Many studies have shown dopamine (DA) to have a modulatory effect on neuronal excitability, which cannot be simply classified as excitatory or inhibitory in the neostriatum. To clarify whether the responses to DA (10-30 microM) are excitatory or inhibitory in the mouse medium spiny neurons, we examined the effects of DA agonists on the synchronous potential(More)
Extracellular unit recordings were obtained from neurons in the ventral tegmental area (VTA), the substantia nigra, zona compacta (SNC) and zone reticulata (SNR) of adult female albino rats anaesthetized with urethane and chloral hydrate. Neurons were divided into two types based on their electrophysiological characteristics; Type I neurons had long(More)
PURPOSE To investigate the relationship between ornithine-delta-aminotransferase (OAT) deficiency and ornithine accumulation and the specific degeneration of retinal pigment epithelial (RPE) cells in gyrate atrophy. METHODS Human RPE cells, human hepatoma cells, and human fibroblast cells were treated with 5-fluoromethylornithine (5-FMOrn), a specific(More)
We examined the differences between the results of an automatic sleep analysis system and inspection decision. Subjects were 10 males (average age 21.6 years). One section consists of 20 s records. The sections that deviated from the algorithm could not be decided. Each sleep stage decided by automatic analysis was compared with the inspection decision. The(More)