Hisanao Akita

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In view of recent findings that suggest that the nigrostriatal dopamine (DA) system plays a role in motor control and the acquisition of habits and skills, we hypothesized that the striatum-based function underlying the acquisition of skilled behaviors might be more vulnerable to dopamine depletion than the motor control. To test this hypothesis, we(More)
To examine the role of mGluR1 (a subunit of the group I metabotropic glutamate receptor) in the nociceptive responses of rats following a subcutaneous injection of formalin into the plantar surface of the hind paw, we delivered antisense oligonucleotides (ODNs) against mGluR1 into the rat lumbar spinal cord (L3-L5) intrathecally using an(More)
To test the hypothesis that the cellular mechanism whereby chronic deep brain stimulation of the subthalamic nucleus (STN-DBS) induces the improvement of motor deficits lasting after stimulation in the hemiparkinsonian (hemi-PD) rat involves the NMDA receptor-dependent processes in neurons receiving afferents from the STN, we examined whether the NMDA(More)
Paclitaxel, one of the chemotherapeutic agents clinically used to treat several types of cancer, produces side effects such as peripheral neuropathy, sensory abnormalities, and hyperalgesia. Since hyperalgesia remains after cessation of paclitaxel therapy and becomes chronic, we hypothesize that alteration in memory and the cognitive process of pain(More)
In urethan-anesthetized rats, unitary discharges of wide dynamic range (WDR) neurons were extracellularly recorded from the lumber cord. Repetitive electrical shocks were delivered through needle electrodes in the receptive field with sufficient strength to activate C fibers. The number of evoked discharges was compared before and after application of(More)
To produce an animal model of a dopa-responsive motor disorder with depletion of dopamine (DA) release in the striatum by dysfunction of the transmitter release machinery of the nigrostriatal DA system, we performed an intra-nigral injection of an HVJ-liposome gene transfer vector containing antisense oligodeoxynucleotides (ODNs) against synaptotagmin I(More)
The use of NR2B antagonists in Parkinsonism is still controversial. To examine their anti-parkinsonian effects, the NR2B antagonist, ifenprodil, and L-DOPA were administered together and separately in hemiparkinsonian rats (hemi-PD) that were subjected to a cylinder test. Recovery from hypoactivity was achieved by single administration of 3-7 mg/kg of(More)
Objectives: The antiparkinsonian effect of N-methyl-D-aspartate (NMDA) receptor subtype 2B (NR2B) antagonists remain controversial. To determine the effects of NR2B antagonist on Parkinson's disease (PD), the effect of a single administration of D1R agonist SKF38393 (SKF) and NR2B antagonist ifenprodil or co-administration of ifenprodil and SKF were(More)
Rats with dopamine depletion caused by 6-hydroxydopamine (6-OHDA) treatment during adulthood and the neonatal period exhibit akinetic motor activity and spontaneous motor hyperactivity during adolescence, respectively, indicating that the behavioral effects of dopamine depletion depend on the period of lesion development. Dopamine depletion during adulthood(More)
In 1940, Hardy had developed a method of radiant heat stimulation and succeeded to determine pain threshold quantitatively. An algometer NYT-55 was developed according to his principle by Nakahama and Yamamoto, which was a further developed version of Hardy's model. In the present study, pain threshold and tolerance threshold were measured quantitatively,(More)
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