Learn More
We describe Trans-ABySS, a de novo short-read transcriptome assembly and analysis pipeline that addresses variation in local read densities by assembling read substrings with varying stringencies and then merging the resulting contigs before analysis. Analyzing 7.4 gigabases of 50-base-pair paired-end Illumina reads from an adult mouse liver poly(A) RNA(More)
Using DNA sequences 5' to open reading frames, we have constructed green fluorescent protein (GFP) fusions and generated spatial and temporal tissue expression profiles for 1,886 specific genes in the nematode Caenorhabditis elegans. This effort encompasses about 10% of all genes identified in this organism. GFP-expressing wild-type animals were analyzed at(More)
Array comparative genomic hybridization (aCGH) has been used primarily to detect copy-number variants between two genomes. Here we report using aCGH to detect single nucleotide mutations on oligonucleotide microarrays with overlapping 50-mer probes. This technique represents a powerful method for rapidly detecting novel homozygous single nucleotide(More)
Short description: This report presents the state of the art of research in adaptive service generation as an enabling step toward automatic code generation. The relevant scientific results , computational problems and infrastructural implications are presented with the aim of providing the basis for the foundation of a computational theory for Digital(More)
Anterior organization of the C. elegans embryo by the labial-like Hox gene ceh-13 Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. The pattern of neuroblast formation, mitotic domains and proneural gene expression during early brain development in Drosophila. Functional analysis of the single calmodulin gene in the(More)
The goal of fast adaptations and modifications according to continuous change requests is common to all software engineering methodologies. In most cases, sooner or later this results in a mismatch between the software specification and the actual implementation with related disadvantages such as the impossibility of performing validations of related(More)
  • 1