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OBJECTIVE Screening with low-dose spiral CT is a promising new tool for early lung cancer detection. A study was undertaken to assess the prevalence of emphysema detected by CT screening, and to assess the correlation between the extent of emphysema and the severity defined according to the recently published Global Initiative for Chronic Obstructive Lung(More)
OBJECTIVE The effects of cigarette smoking and smoking cessation on age-related pulmonary function decline was assessed in both cross-sectional and longitudinal studies. METHODOLOGY In the cross-sectional study, pulmonary function data from 11,875 healthy asymptomatic males, aged between 35 and 74, were analysed and correlated with their smoking history(More)
BACKGROUND The aim of this cross-sectional study was to investigate the association between airflow obstruction and the metabolic syndrome (MS) or its components in Japanese men. METHODS The study included 7,189 male subjects, aged 45-88 years, who underwent spirometric lung function tests at a medical check-up. The spirometric criteria for diagnosis of(More)
OBJECTIVES Arylamines are considered to be the primary causative agent of bladder cancer in tobacco smokers. To test the hypothesis that variation in the genes that metabolize tobacco carcinogens contribute to bladder cancer, we examined the effects of single nucleotide polymorphisms in the genes of four key enzymes: cytochrome P450 1A2, N-acetyltransferase(More)
A longitudinal study was conducted to investigate the relation between the changes of bone mineral density (BMD) over a seven-year period and A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 (LRP5) gene or lifestyle factors. The subjects were 113 premenopausal female employees from a large-scale integrated manufacturing facility(More)
OBJECTIVES Both genetic and lifestyle factors have been shown to influence bone mineral density (BMD). We investigated the correlations between BMD and low-density lipoprotein receptor-related protein 5 (LRP5) A1330V (rs3736228) polymorphism, exercise, smoking, and alcohol intake in Japanese male workers. METHODS The subjects were 829 male employees (aged(More)
OBJECTIVES Chronic kidney disease (CKD) is a major public health problem. Epidemiological studies of the relationship between alcohol intake and CKD are scarce in Japan. This cross-sectional study aims to investigate the relationship between frequency of drinking alcohol and CKD in Japanese men. METHODS The subjects were 9,196 men (mean ± standard(More)
PURPOSE OF REVIEW There is increasing interest in using multichannel computed-tomography scanning in the characterization of subjects with chronic obstructive pulmonary disease. Three distinct components - emphysema, large-airway inflammation and small-airway abnormality - have been evaluated using qualitative and quantitative approaches. Here we highlight(More)
OBJECTIVES The aim of this cross-sectional study was to investigate the association between bone mineral density (BMD) and lifestyle factors, as well as the influence of vitamin D receptor (VDR) gene polymorphism, in adult male workers. METHODS The subjects were 524 male employees aged 23-49 years (37.3 +/- 5.4 years, mean +/- standard deviation) working(More)
Phenyl-substituted dihydropyrazines (Ph-DHPs) are derivatives of 2,3-dihydro-5,6-dimethylpyrazine (Me-DHP). Upon the addition of Cu(2+), Me-DHP inhibits the growth of Escherichia coli by generating hydroxyl and carbon-centered radicals that cause DNA strand breakage. Here, we investigated the toxic effect of Ph-DHPs in several DNA repair-deficient or(More)