Hisako Matsui-Hirai

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For functional assessment of gene therapy in experimental animals, in vivo assessment of transferred genes will provide a major advance over an in vitro analysis which must be done post-hoc. In the current study we conducted positron emission tomography (PET) analysis in rats following injection of the adenoviral vector encoding the cDNA for the rat(More)
OBJECTIVE We investigated the effect of glimepiride, a third-generation sulfonylurea hypoglycemic agent, on insulin resistance in elderly patients with type 2 diabetes, in connection with plasma adiponectin and 8-epi-prostagrandin F2alpha (8-epi-PGF2alpha), an oxidative stress marker. RESEARCH DESIGN AND METHODS A total of 17 elderly patients with type 2(More)
In this report, we demonstrate that NADPH oxidase is activated by tumor necrosis factor-a (TNF-a) plus interferon-g (IFN-g) in human monocytic cells (THP-1 cells) differentiated with phorbol ester (PMA) and that physiological concentration of 17h-estradiol inhibits NADPH oxidase activity in THP-1 cells stimulated with TNF-a plus IFN-g. This effect is(More)
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