Hisako Ishikawa

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Both mizoribine (MZR) and mycophenolate mofetil (MMF) are immunosuppressive agents that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH. MZR is a nucleoside of the imidazole class, isolated from the culture medium of the mold Eupenicillium brefeldianum M-2166. Although this compound has been found to have weak antimicrobial(More)
Fascicles of microtubules, previously considered to be unique to the initial segments of myelinated axons, were found at nodes of Ranvier of sensory and motor axons in rat spinal roots, though their occurrence was limited to the proximal portion of the axons. No fasciculated microtubules were noticed in the internodes of myelinated axons or in unmyelinated(More)
Embryogenic cells (ECs) of sugi (Cryptomeria japonica D. Don) were induced from immature and mature zygotic embryos cultured on different concentrations of 2,4-dichlorophenoxyacetic acid (2,4-D)-containing modified Campbell and Durzan medium. The rate of induction of ECs varied depending on the stage of embryos collected. The highest percentage of induction(More)
Astrocytic end-feet in the rat CNS were studied by thin section electron microscopy. Astrocyte processes that enclose neuronal elements extended to blood vessels and the pia mater, where the processes expanded to form end-feet or glial limiting membranes. At the end-feet, cell junctions such as gap junctions and desmosome-like junctions were formed between(More)
Both the development of red pulp and hemopoietic activity in spleen obtained from 62 human embryos and fetuses between 30 days and 20 weeks after ovulation were investigated light and electron microscopically. The spleen develops in the left-posterior portion of the dorsal mesogastrium at 35-40 days after ovulation. At the 8th week after ovulation,(More)
The mode in which the force exerted by the contraction of myofibrils is transmitted to tendon has been debated for many years (as reviews HAGGQVIST 1931 and 1956). It is generally accepted that the major union of muscle with tendon is established at the end of muscle fibers. Light-microscopically, two main opposing theories appear in the literature(More)
Pseudorabies virus grown in CPK cell cultures was tested for hemagglutination (HA) with erythrocytes of a variety of species at 4°C, 25°C and 37°C. HA was observed at all temperatures with mouse erythrocytes but not with cattle, sheep, goat, swine, cat, rabbit, guinea pig, rat, mongolian gerbil, chicken, and goose erythrocytes. Mice showed a strain(More)
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