Hisaka Saito

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Growth factors and tumor-promoting phorbol esters induce various types of "early response" genes, most of which encode transcription factors. To identify possible target genes for these early response gene products, we isolated complementary DNA clones of genes that were induced later by 12-O-tetradecanoylphorbol-13-acetate. A complementary DNA library was(More)
Change in the level of CuZn-superoxide dismutase (SOD) mRNA was examined using a molecular probe during differentiation of human monocytic leukemia U937 cells or promyelotic leukemia HL-60 cells induced by either 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or dimethylsulfoxide (DMSO). CuZn-SOD mRNA levels were found to decrease during the course of(More)
Neuritic plaques are the key pathological feature of Alzheimer's disease, and amyloid beta (Abeta) peptides are major component of these plaques. In this study, we demonstrated the influence of aluminum (Al) on the Abeta peptide degradation by cathepsin D. Al did not directly affect the cathepsin D activity using small synthetic substrate. However, when(More)
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