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We have developed a three-dimensional (3-D) computer-aided diagnosis scheme for automated detection of colonic polyps in computed tomography (CT) colonographic data sets, and assessed its performance based on colonoscopy as the gold standard. In this scheme, a thick region encompassing the entire colonic wall is extracted from an isotropic volume(More)
The purpose of this study was to apply a novel method of multiscale echo texture analysis for distinguishing benign (hemangiomas) from malignant (hepatocellular carcinomas (HCCs) and metastases) focal liver lesions in B-mode ultrasound images. In this method, regions of interest (ROIs) extracted from within the lesions were decomposed into subimages by(More)
Homeobox genes encode transcription factors that control cell differentiation and play essential roles in developmental patterning. Increasing evidence indicates that many homeobox genes are aberrantly expressed in cancers, and that their deregulation significantly contributes to tumor progression. The homeobox gene HOXA10 controls uterine organogenesis(More)
PURPOSE To develop a computer-aided diagnosis (CAD) scheme for automated detection of colonic polyps on the basis of volumetric features and to assess its accuracy on the basis of colonoscopy, the standard. MATERIALS AND METHODS Computed tomographic (CT) colonography was performed in patients with use of standard bowel cleansing, air insufflation, and(More)
The role of MRI in assessing facet joint osteoarthritis is unclear. By developing a grading system for severity of facet joint osteoarthritis on MRI, the relationship between disc degeneration and facet joint osteoarthritis was determined. The accuracy of MRI in assessing facet joint osteoarthritis against CT was 94%. Under 40 years of age, the degree of(More)
PURPOSE To develop a three-dimensional (3D) segmentation and computerized volumetry technique for use in the assessment of neurofibromatosis and to assess the ability of this technique to aid in the calculation of tumor burden in patients with neurofibromatosis types 1 and 2 (NF1 and NF2, respectively) and schwannomatosis detected with whole-body magnetic(More)
CT colonography, or virtual colonoscopy, is a promising alternative screening tool for colon cancer. Computer-aided diagnosis (CAD) for CT colonography has the potential to increase radiologists' diagnostic performance in the detection of polyps and to reduce variability of the diagnostic accuracy among readers. Technical developments have advanced CAD for(More)
Computed tomographic colonography (CTC), also known as virtual colonoscopy, is an emerging alternative technique for screening of colon cancers. CTC uses CT to provide a series of cross-sectional images of the colon for detection of polyps and masses. Fecal tagging is a means of labeling of residual feces by an oral contrast agent for improving the accuracy(More)
We evaluated the effect of our novel technique of feature-guided analysis of polyps on the reduction of false-positive (FP) findings generated by our computer-aided diagnosis (CAD) scheme for the detection of polyps from computed tomography colonographic data sets. The detection performance obtained by use of feature-guided analysis in the segmentation and(More)
PURPOSE We have developed a novel automated technique for segmenting colonic walls for the application of computer-aided polyp detection in CT colonography. In particular, the technique was designed to minimize the presence of extracolonic components, such as small bowel, in the segmented colon. METHODS The segmentation technique combines an improved(More)