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We have discovered an unusual homeodomain protein, called HOP, which is comprised simply of a homeodomain. HOP is highly expressed in the developing heart where its expression is dependent on the cardiac-restricted homeodomain protein Nkx2.5. HOP does not bind DNA and acts as an antagonist of serum response factor (SRF), which regulates the opposing(More)
BACKGROUND Inositol 1,4,5-trisphosphate receptors (IP3R1, 2, and 3) are intracellular Ca2+ release channels that regulate various vital processes. Although the ryanodine receptor type 2, another type of intracellular Ca2+ release channel, has been shown to play a role in embryonic cardiomyocytes, the functions of the IP3Rs in cardiogenesis remain unclear.(More)
Serial data links are often designed targeting a specific transmission medium. High-speed links using different predetermined transmission media have been demonstrated in the past [1-3]. This, however, restricts user's ability to use an integrated link interface with other transmission media once the chip is fabricated. For example, traditional transceivers(More)
During pregnancy, progesterone inhibits the growth-promoting actions of estrogen in the uterus. However, the mechanism for this is not clear. The attenuation of estrogen-mediated proliferation of the uterine epithelium by progesterone is a prerequisite for successful implantation. Our study reveals that progesterone-induced expression of the basic(More)
—This paper presents a 60-GHz direct-conversion RF front-end and baseband transceiver including analog and digital circuitry for PHY functions. The 65-nm CMOS front-end consumes 319 and 223 mW in transmitting and receiving mode, respectively. It is capable of more than 7-Gb/s 16QAM wireless communication for every channel of the 60-GHz standards, which can(More)
We have purified extrachromosomal circular DNAs from adult mouse spleen cells, and cloned into a phage vector the BamHl fragments hybridizing with C mu and S gamma 1 probes. We obtained 52 S mu+S gamma 1+ clones by screening 1.4 million phage clones derived from spleen cells stimulated with bacterial lipopolysaccharide and interleukin 4. We have identified(More)
—A new interconnect solution with plastic waveguide is demonstrated. The system consists of a pair of transceivers and a plastic waveguide. Millimeter wave signal is transmitted in a low-cost long piece of solid plastic dielectric acting as a waveguide. The plastic waveguide medium offers a large bandwidth for data communication using mm-wave carrier(More)
The origin and developmental mechanisms underlying coronary vessels are not fully elucidated. Here we show that myocardium-derived angiopoietin-1 (Ang1) is essential for coronary vein formation in the developing heart. Cardiomyocyte-specific Ang1 deletion results in defective formation of the subepicardial coronary veins, but had no significant effect on(More)