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  • Hiroyuki Yakushiji, Fabrice Maraboeuf, +4 authors Mutsuo Sekiguchi
  • Biology, Medicine
  • Mutation research
  • 1997 (First Publication: 1 September 1997)
  • 8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) is produced during cellular metabolism, and its misincorporation into DNA causes mutation. Human cells possess an enzyme thatContinue Reading
  • Naohiko Kohya, Kohji Miyazaki, +6 authors Mutsuo Sekiguchi
  • Biology
  • 2002 (First Publication: 1 May 2002)
  • Background O 6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that transfers methyl groups fromO 6-methylguanine to itself. Alkylation of DNA at theO 6 position of guanine is anContinue Reading
  • Dale W. Porter, Hiroyuki Yakushiji, Yusaku Nakabeppu, Mutsuo Sekiguchi, Matthew J. Fivash, Kazimierz S. Kasprzak
  • Biology, Medicine
  • Carcinogenesis
  • 1997 (First Publication: 1 September 1997)
  • The toxicity of Ni(II), Co(II) and Cu(II) in animals, and that of Cd(II) in cultured cells, has been associated with generation of the promutagenic lesion 8-oxo-7,8-dihydroguanine (8-oxoguanine) inContinue Reading
  • Masayuki Takahashi, Fabrice Maraboeuf, +7 authors Yusaku Nakabeppu
  • Chemistry, Medicine
  • Journal of molecular biology
  • 2002 (First Publication: 1 May 2002)
  • The human MTH1 antimutator protein hydrolyzes mutagenic oxidized nucleotides, and thus prevents their incorporation into DNA and any subsequent mutation. We have examined its great selectivity forContinue Reading
  • Katsuyoshi Fujikawa, Hisao Kamiya, Hiroyuki Yakushiji, Y. Fujii, Yusaku Nakabeppu, Hiroshi Kasai
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 1999 (First Publication: 25 June 1999)
  • The possibility that Escherichia coli MutT and human MTH1 (hMTH1) hydrolyze oxidized DNA precursors other than 8-hydroxy-dGTP (8-OH-dGTP) was investigated. We report here that hMTH1 hydrolyzedContinue Reading