Hiroyuki Uesaka

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A measure of interaction between treatments and stratum is proposed when there are two treatments and the response variable is measured on an ordered categorical scale. A test of the hypothesis of no interaction and a test of the hypothesis of no treatment effect are given and approximate expressions for the powers of these tests are obtained. Monte Carlo(More)
In similarly designed clinical trials conducted in different regions or a multiregional trial, we sometimes observe different mean responses between trials or regions due to differences in distributions of an ethnic factor. Uesaka et al. ( 2003 ) used adjusted means for covariate, the distribution adjusted mean, to deal with such a situation. This paper(More)
The objective of a multiregional bridging trial is to show the efficacy of a drug in various global regions, and at the same time to evaluate the possibility of applying the overall trial results to each region. However, to apply overall results to a specific region, the result in that region should be consistent with either the overall results or the(More)
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