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Basic fibroblast growth factor-responsive neural stem cells (NSCs) derived from adult rat hippocampus were earlier demonstrated to generate neurons and glia. These stem-cell-derived neurons express GABA, acetylcholinesterase, tyrosine hydroxylase, or calbindin. It has not been clear, however, whether or not these stem-cell-derived neurons are able to form(More)
Topics mentioned in blogspace are biased towards interesting/ funny or entertainment-related topics compared to articles in the generic web space and there are many personal opinions on products or services. Making good use of these characteristics, we introduce a new blog search engine that provides multiple interfaces, each targeted at a different goal,(More)
We propose a new method for estimating user attributes (gender, age, occupation, and interests) of a Twitter user from the user's contents (profile document and tweets) and social neighbors, i.e. those whom the user has mentioned. Our labeling method is able to collect a large amount of training data automatically by using Twitter users associated with a(More)
Neurogenesis in the adult dentate gyrus (DG) is considered to be partly involved in the action of mood stabilizers. However, it remains unclear how mood stabilizers affect neural precursor cells in adult DG. We have established a culture system of adult rat DG-derived neural precursor cells (ADP) and have shown that lithium, a mood stabilizer, and(More)
To determine the possible therapeutic potential of neural stem cells (NSCs) introduced into the damaged central nervous system, we grafted adult hippocampus-derived NSCs into the hippocampus of rats with transient global ischemia. Transient four-vessel occlusion yielded 90-95% losses of pyramidal neurons in the hippocampal CA1 region. In this region, 1-3%(More)
Stress during postnatal development is associated with an increased risk for depression, anxiety disorders, and substance abuse later in life, almost as if mental illness is able to be programed by early life stressors. Recent studies suggest that such "programmed" effects can be caused by epigenetic regulation. With respect to conditioned fear, previous(More)
The splicing of 26 nucleotides in the coding region of the X-box binding protein-1 (XBP-1) transcript to generate a mature active transcription factor is a part of the unfolded protein response to intracellular endoplasmic reticulum stress. In this study, we demonstrated that XBP-1 splicing is promptly induced in the rat brain including the hippocampus by(More)
The putative antidepressive mechanisms of a series of electroconvulsive seizures (ECS) are the following: 1) downregulation of monoaminergic receptor expression in several brain regions, 2) upregulation of the expression of brain-derived neurotrophic factor (BDNF), and 3) increased neurogenesis in the hippocampus. In this study, we used Western blot(More)
Clustering the results of a search helps the user to overview the information returned. In this paper, we regard the clustering task as indexing the search results. Here, an index means a structured label list that can makes it easier for the user to comprehend the labels and search results. To realize this goal, we make three proposals. First is to use(More)