Hiroyuki Sakai

Learn More
Hemophagocytic syndrome is a systemic reactive histiocytic proliferative disorder affecting the reticuloendothelial system. Skin lesions develop in 12.5% to 55.6% of the patients. We report a 35-year-old woman with systemic lupus erythematosus and Graves' disease complicated with parvovirus B19-associated hemophagocytic syndrome. She presented with slightly(More)
Kawasaki disease is an acute febrile disease predominantly seen in young children. We report a case of Kawasaki disease in a 32-year-old pregnant woman. She developed a generalized erythematous skin rash accompanied by high fever. Bilateral conjunctival congestion, tender cervical lymphadenopathy, an edematous lower lip and peripheral edema followed by(More)
A 60-year-old woman presented with a 13-day history of a generalized erythematous rash accompanied by fever, periorbital edema and axillary lymphadenopathy. Prior to the appearance of the rash, the patient had been treated with intermittent courses of oral minocycline for cystitis. The patient was diagnosed with drug-induced hypersensitivity syndrome (DIHS)(More)
Technology scaling and Moore’s law have paved the way for ever faster transistors, with device unity gain frequency (ft) exceeding 100GHz for today’s 90nm CMOS technology. The realization of functional circuits operating at or above the device ft is a challenging task, and the subject of much of this session, with demonstrations of circuits operating above(More)
Cutaneous larva migrans is caused by various nematodes. Skin manifestations may include superficial or creeping eruptions, folliculitis, and migratory subcutaneous nodules. We report a 52-year-old man with asymptomatic, multiple eruptive papules and nodules on the face and neck caused by the larvae of an unknown nematode. The patient never had any creeping(More)
Anti-tumor necrosis factor α (TNF-α) biologic agents are used for treating refractory sarcoidosis. However, sarcoidosis-like epithelioid cell granulomas may develop during anti-TNF-α treatment. A 63-year-old man suffering from rheumatoid arthritis was treated with oral methotrexate and methylprednisolone for 4 years. He subsequently started biweekly(More)
Using mouse peritoneal mast cells, we investigated the effects of 1α,25-dihydroxyvitamin D3 (calcitriol) on mast cell proliferation and histamine release. Calcitriol did not affect IL-3/IL-4-dependent mast cell proliferation, but it selectively inhibited stem cell factor-dependent mast cell proliferation and colony formation. Immunohistochemical and(More)
We report two cases of drug-induced vasculitis subsequent to long-term minocycline therapy. Case 1; A 27-year-old woman, who was receiving minocycline hydrochloride for eosinophilic pustular folliculitis of 68-months'duration, showed polyarthralgia, intermittent low-grade fever, and light red reticulated erythemas with subcutaneous nodules on her(More)
This paper describes concepts and performance of millimeter-wave flip-chip IC and power amplifier using MBB (Micro Bump Bonding) technology. Two types of flip-chip technologies, MFIC (Millimeter-wave Flip-chip IC) and MBS (Micro Bump on Source electrode) technologies are introduced, and their applications to a K-band receiver front-end IC and a K-band power(More)
Acetylcholinesterase (AChE) activity was topographically investigated in the presumptive cardiac conduction tissue regions visualized by HNK-1 immunoreactivity in rat embryos, and AChE-positive cells were examined with the electron microscope. On embryonic day (ED) 14.5, when HNK-1 was most intensely visualized, AChE activity could not be detected(More)