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  • De-sheng Wang, Johan W. Jonker, Yukio Kato, Hiroyuki Kusuhara, Alfred H. Schinkel, Yuichi Sugiyama
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental…
  • 2002 (First Publication: 1 August 2002)
  • Metformin, a biguanide, is widely used as an oral hypoglycemic agent for the treatment of type 2 diabetes mellitus. The purpose of the present study was to investigate the role of organic cationExpand
  • Takao Watanabe, Hiroyuki Kusuhara, Kazuya Maeda, Yoshihisa Shitara, Yuichi Sugiyama
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental…
  • 2009 (First Publication: 1 February 2009)
  • Hepatobiliary excretion mediated by transporters, organic anion-transporting polypeptide (OATP) 1B1 and multidrug resistance-associated protein (MRP) 2, is the major elimination pathway of an HMG-CoAExpand
  • Tomoki Imaoka, Hiroyuki Kusuhara, Masashi Adachi, John D. Schuetz, Kenji Takeuchi, Yuichi Sugiyama
  • Chemistry, Medicine
  • Molecular Pharmacology
  • 2007 (First Publication: 1 February 2007)
  • Acyclic nucleotide phosphonates (adefovir, cidofovir, and tenofovir) are eliminated predominantly into the urine, and renal failure is their dose-limiting toxicity, particularly for adefovir andExpand
  • Hiroshi Kodaira, Hiroyuki Kusuhara, Junko Ushiki, Eiichi Fuse, Yuichi Sugiyama
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental…
  • 2010 (First Publication: 1 June 2010)
  • A synergistic effect of P-glycoprotein (P-gp)/Abcb1a and breast cancer resistance protein (Bcrp)/Abcg2 was reported to limit the brain penetration of their common substrates. This study investigatedExpand
  • Daisuke Sugiyama, Hiroyuki Kusuhara, +4 authors Yuichi Sugiyama
  • Medicine, Biology, Chemistry
  • Journal of Biological Chemistry
  • 2003 (First Publication: 31 October 2003)
  • Oatp14/blood-brain barrier-specific anion transporter 1 (Slc21a14) is a novel member of the organic anion transporting polypeptide (Oatp/OATP) family. Northern blot analysis revealed predominantExpand
  • Maki Hasegawa, Hiroyuki Kusuhara, +4 authors Yuichi Sugiyama
  • Medicine, Chemistry
  • The Journal of pharmacology and experimental…
  • 2002 (First Publication: 1 March 2002)
  • Our previous kinetic analyses have shown that the transporter responsible for the renal uptake of pravastatin, an HMG-CoA reductase inhibitor, differs from that involved in its hepatic uptake.Expand
  • Harunobu Tahara, Hiroyuki Kusuhara, +4 authors Yuichi Sugiyama
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental…
  • 2005 (First Publication: 1 October 2005)
  • A clinical drug-drug interaction between famotidine (a H2 receptor antagonist) and probenecid has not been reproduced in rats. The present study hypothesized that the species-dependent probenecidExpand
  • Sumito Ito, Hiroyuki Kusuhara, +8 authors Yuichi Sugiyama
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental…
  • 2010 (First Publication: 1 April 2010)
  • This report describes a potent and selective inhibitor of multidrug and toxin extrusion (MATE) protein, pyrimethamine (PYR), and examines its effect on the urinary and biliary excretion of typicalExpand