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The serine racemase mRNA is predominantly expressed in rat brain neurons.
This is the first study to demonstrate the exact localization of serine racemase mRNA at the cellular or tissue level and suggests that neuron-derived D-serine could modulate neurotransmission via the glycine site of N-methyl-D-aspartate receptors. Expand
Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase.
The results indicate the elevated D-serine level following the chronic morphine treatment could at least in part be involved in the activation of NMDA receptors via the glycine site. Expand
Acute treatment with morphine augments the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain.
The present results are the first to suggest an interaction between the expression of the mRNAs for the D-serine-related enzymes and the opioid receptor activation. Expand
Cysteinyl leukotriene receptor antagonists inhibit tumor metastasis by inhibiting capillary permeability.
Results show that pranlukast can inhibit tumor cell migration through both the brain and peripheral capillaries, whereas montelukast inhibits tumor cell Migration only in the peripheral capillsaries. Expand
Effects of MK-801 on the expression of serine racemase and d-amino acid oxidase mRNAs and on the D-serine levels in rat brain.
The present findings indicate that increasing the serine racemase mRNA and no changes in the DAO mRNA after the chronic administration could contribute to the elevation of the d-serine level in the forebrain, and that serine Racemase and DAO could play an important role in the regulation of N-methyl-d-aspartate receptors via the d -serine metabolism. Expand
Great increase in antinociceptive potency of [Leu5]enkephalin after peptidase inhibition.
It is shown that amastatin-, captopril-, and phosphoramidon-sensitive enzymes play important roles in the inactivation of short endogenous opioid peptides, such as penta-, hepta-, and octa-peptides, administered intra-third-ventricularly to rats. Expand
VEGF signaling is disrupted in the hearts of mice lacking estrogen receptor alpha.
Estrogen has widely been credited for cardioprotection in women. However, the exact mechanisms that underlie these beneficial estrogenic effects are not completely understood. Here, we sought to: 1)Expand
Tracheal instillation of diesel exhaust particles component causes blood and pulmonary neutrophilia and enhances myocardial oxidative stress in mice.
It was concluded that particle component of DEP may enhance myocardial oxidative stress via blood neutrophilia and the elevation of cytokine levels in BALF. Expand
Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain
The present data suggest that activation of NMDA receptors via glycine sites at the supraspinal level induces an antinociceptive effect on both acute and tonic pain. Expand
Expression of the mRNA and protein of serine racemase in primary cultures of rat neurons.
These data are the first to demonstrate that a substantial amount of serine racemase exists in the cultured neurons, and reveal that serine Racemase and MAP2 are co-localized in the neurons. Expand