Hiroyuki Hori

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Deep knot structure for construction of active site and cofactor binding site of tRNA modification enzyme.

Osamu Nureki, Kazunori Watanabe, +4 authors Shigeyuki Yokoyama
Structure
2004

The tRNA(Gm18) methyltransferase (TrmH) catalyzes the 2'-O methylation of guanosine 18 (Gua18) of tRNA. We solved the crystal structure of Thermus thermophilus TrmH complexed with… (More)

Roles of conserved amino acid sequence motifs in the SpoU (TrmH) RNA methyltransferase family.

Kazunori Watanabe, Osamu Nureki, +5 authors Hiroyuki Hori
The Journal of biological chemistry
2005

Transfer RNA (Gm18) methyltransferase (TrmH (SpoU)) catalyzes the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to the 2'-OH of guanosine 18 in tRNA. This enzyme is a member of the… (More)

N7-Methylguanine at position 46 (m7G46) in tRNA from Thermus thermophilus is required for cell viability at high temperatures through a tRNA modification network

Chie Tomikawa, Takashi Yokogawa, Tamotsu Kanai, Hiroyuki Hori
Nucleic acids research
2010

N(7)-methylguanine at position 46 (m(7)G46) in tRNA is produced by tRNA (m(7)G46) methyltransferase (TrmB). To clarify the role of this modification, we made a trmB gene disruptant (DeltatrmB) of… (More)

The 2′-O-methylation status of a single guanosine controls transfer RNA–mediated Toll-like receptor 7 activation or inhibition

Stefanie Jöckel, Gernot Nees, +8 authors Stefan Bauer
The Journal of experimental medicine
2012

Foreign RNA serves as pathogen-associated molecular pattern (PAMP) and is a potent immune stimulator for innate immune receptors. However, the role of single bacterial RNA species in immune… (More)

Functional categorization of the conserved basic amino acid residues in TrmH (tRNA (Gm18) methyltransferase) enzymes.

Kazunori Watanabe, Osamu Nureki, Shuya Fukai, Yaeta Endo, Hiroyuki Hori
The Journal of biological chemistry
2006

Transfer RNA (Gm18) methyltransferase (TrmH) catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the G18 ribose in tRNA. To identify amino acid residues… (More)

Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product.

Sawa Hirotsu, Yoshito Abe, +4 authors Toshio Hakoshima
Proceedings of the National Academy of Sciences…
1999

Heme-binding protein 23 kDa (HBP23), a rat isoform of human proliferation-associated gene product (PAG), is a member of the peroxiredoxin family of peroxidases, having two conserved cysteine… (More)

Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine…

Tomoko Nishino, Ken Okamoto, +5 authors Takeshi Nishino
The Journal of biological chemistry
2005

Mammalian xanthine dehydrogenase can be converted to xanthine oxidase by modification of cysteine residues or by proteolysis of the enzyme polypeptide chain. Here we present evidence that the… (More)

Substrate tRNA recognition mechanism of tRNA (m7G46) methyltransferase from Aquifex aeolicus.

Hironori Okamoto, Kazunori Watanabe, Yoshiho Ikeuchi, Tsutomu Suzuki, Yaeta Endo, Hiroyuki Hori
The Journal of biological chemistry
2004

Transfer RNA (m7G46) methyltransferase catalyzes the methyl transfer from S-adenosylmethionine to N7 atom of the guanine 46 residue in tRNA. Analysis of the Aquifex aeolicus genome revealed one… (More)

Antenatal dietary education and supplementation to increase energy and protein intake.

Erika Ota, Hiroyuki Hori, Rintaro Mori, Ruoyan Tobe-Gai, Diane Farrar
The Cochrane database of systematic reviews
2015

BACKGROUND Gestational weight gain is positively associated with fetal growth, and observational studies of food supplementation in pregnancy have reported increases in gestational weight gain and… (More)

Pseudouridine at position 55 in tRNA controls the contents of other modified nucleotides for low-temperature adaptation in the extreme-thermophilic eubacterium Thermus thermophilus

Kazuo Ishida, Takashi Kunibayashi, +5 authors Hiroyuki Hori
Nucleic acids research
2011

Pseudouridine at position 55 (Ψ55) in eubacterial tRNA is produced by TruB. To clarify the role of the Ψ55 modification, we constructed a truB gene disruptant (ΔtruB) strain of Thermus thermophilus… (More)

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