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Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist
Lysophosphatidic acid (LPA) is a pluripotent lipid mediator acting through plasma membrane-associated LPAx receptors that transduce many, but not all, of its effects. We identify peroxisomeExpand
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Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation.
Consumption of foods high in saturated fatty acids (FAs) as well as elevated levels of circulating free FAs are known to be associated with T2D. Though previous studies showed inflammation isExpand
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LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing
Every successful pregnancy requires proper embryo implantation. Low implantation rate is a major problem during infertility treatments using assisted reproductive technologies. Here we report a newlyExpand
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Vitamin E decreases bone mass by stimulating osteoclast fusion
Bone homeostasis is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption. Osteoclasts are multinucleated cells that are formed by mononuclear preosteoclastExpand
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TGFα shedding assay: an accurate and versatile method for detecting GPCR activation
A single-format method to detect multiple G protein–coupled receptor (GPCR) signaling, especially Gα12/13 signaling, presently has limited throughput and sensitivity. Here we report a transformingExpand
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Expression patterns of the lysophospholipid receptor genes during mouse early development
Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine‐1‐phosphate (S1P) are known to mediate various biological responses, including cell proliferation, migration, andExpand
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MBR-1, a Novel Helix-Turn-Helix Transcription Factor, Is Required for Pruning Excessive Neurites in Caenorhabditis elegans
In the developing brain, excessive neurites are actively pruned in the construction and remodeling of neural circuits. We demonstrate for the first time that the pruning of neurites occurs in theExpand
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Lysophosphatidic Acid and Autotaxin Stimulate Cell Motility of Neoplastic and Non-neoplastic Cells through LPA1*
Autotaxin (ATX) is a tumor cell motility-stimulating factor originally isolated from melanoma cell supernatant that has been implicated in regulation of invasive and metastatic properties of cancerExpand
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18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload–induced maladaptive cardiac remodeling
Macrophage-derived 18-HEPE protects mice from cardiac remodeling by preventing proinflammatory activation of cardiac fibroblasts and subsequent fibrosis.
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Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol.
Phosphatidylinositol (PI) is a component of membrane phospholipids, and it functions both as a signaling molecule and as a compartment-specific localization signal in the form ofExpand
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