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  • Akiyoshi Hirayama, Kenjiro Kami, +9 authors Tomoyoshi Soga
  • Biology, Medicine
  • Cancer research
  • 2009 (First Publication: 1 June 2009)
  • Most cancer cells predominantly produce energy by glycolysis rather than oxidative phosphorylation via the tricarboxylic acid (TCA) cycle, even in the presence of an adequate oxygen supply (WarburgExpand
  • Hideharu Kimura, Alessandro Weisz, +6 authors Hiroyasu Esumi
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2001 (First Publication: 19 January 2001)
  • Transcription of hypoxia-inducible genes is regulated by hypoxia response elements (HREs) located in either the promoter or enhancer regions. Analysis of these elements reveals the presence of one orExpand
  • Hideharu Kimura, Alessandro Weisz, +6 authors Hiroyasu Esumi
  • Biology, Medicine
  • Blood
  • 2000
  • Nitric oxide (NO) regulates production of vascular endothelial growth factor (VEGF) by normal and transformed cells. We demonstrate that NO donors may up-regulate the activity of the human VEGFExpand
  • Shigeki Umemura, Sachiyo Mimaki, +18 authors Koichi Goto
  • Medicine
  • Journal of thoracic oncology : official…
  • 2014 (First Publication: 22 August 2014)
  • Introduction: The information regarding therapeutically relevant genomic alterations in small cell lung cancer (SCLC) is not well developed. We analyzed the SCLC genome using an integrative approachExpand