Hiroya Hashimoto

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A QT/QTc study was conducted in compliance with ICH E14 guideline to evaluate the effects of a new xanthine oxidase inhibitor topiroxostat in Japanese healthy subjects. Forty-eight Japanese healthy subjects (males 24; females 24) received a single oral dose of topiroxostat (60 or 180 mg), moxifloxacin (400 mg) or placebo in a single-center, double-blind,(More)
Generation process model of fundamental frequency (F0) contours can well represent F0 movements of speech keeping a clear relation with linguistic information of utterances. Therefore, by using the model, improvement of HMM-based speech synthesis is expected. One of major problems preventing the use of the model is that the performance of automatic(More)
A method was developed to adapt prosody to a new speaker/style in speech synthesis. It is based on predicting differences between target and original speakers/styles and applying them to the original one. Differences in fundamental frequency (F0) contours are represented in the framework of the generation process model; differences in the command(More)
Generation process model of fundamental frequency contours is ideal to represent global features of prosody. It is a command response model, where the commands have clear relations with linguistic and para/non linguistic information conveyed by the utterance. Therefore, by handling fundamental frequency contours in the framework of the generation process(More)
This paper introduces the first online and free framework for teaching and learning Japanese prosody including word accent and phrase intonation. This framework is called OJAD (Online Japanese Accent Dictionary) [1] and it provides three functions. 1) Visual, auditory, systematic, and comprehensive illustration of patterns of accent change (accent sandhi)(More)
Frame-by-frame representation is not appropriate for prosodic features, which are tightly related to speech units spreading a wide time span, such as words, phrases and so on. This causes an inherit problem in fundamental frequency (F<inf>0</inf>) contour generation by HMM-based speech synthesis. A method is developed to modify F<inf>0</inf> contours in the(More)
Through tight collaboration with teachers of Japanese, an online accent dictionary and a reading tutor are developed to support teaching and learning of Japanese prosody. In this development, techniques of natural language processing and spoken language processing are effectively applied. What makes teaching and learning of Japanese accent difficult is the(More)