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Phase 1 study of abemaciclib, an inhibitor of CDK 4 and 6, as a single agent for Japanese patients with advanced cancer
PurposeTo confirm the safety and tolerability, evaluate the pharmacokinetics (PK), and investigate the antitumor activity of abemaciclib in Japanese patients with advanced cancer.MethodsWe conductedExpand
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Phase 1 study of galunisertib, a TGF-beta receptor I kinase inhibitor, in Japanese patients with advanced solid tumors
PurposeInhibition of transforming growth factor-beta receptor I (TGF-beta RI)-mediated signaling pathways blocks tumor growth and metastases in nonclinical studies. Galunisertib (LY2157299), a smallExpand
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Dose‐escalation study of tabalumab with bortezomib and dexamethasone in Japanese patients with multiple myeloma
B‐cell activating factor (BAFF) promotes the survival and adhesion of multiple myeloma (MM) cells. Tabalumab (LY2127399) is an anti‐BAFF monoclonal antibody. This phase 1, multicenter, open‐label,Expand
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Dose‐finding study of the checkpoint kinase 1 inhibitor, prexasertib, in Japanese patients with advanced solid tumors
Prexasertib is a novel inhibitor of checkpoint kinase 1. The primary objective of this study was to evaluate prexasertib tolerability in Japanese patients with advanced solid tumors. ThisExpand
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Automated determination of cardiac rest period on whole-heart coronary magnetic resonance angiography by extracting high-speed motion of coronary arteries.
PURPOSE The aim of the present study was to develop an automated system for determining the cardiac rest period during whole-heart coronary magnetic resonance angiography (CMRA) examination. Expand
[The comparison between dose rates at the interventional reference point of the angiography systems in many facilities].
The management of the radiation dose is very important in interventional radiology (IVR), especially in percutaneous coronary intervention (PCI). Therefore, we measured entrance surface doses at theExpand
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  • Open Access
Development of an automated processing method to detect still timing of cardiac motion for coronary magnetic resonance angiography
Whole-heart coronary magnetic resonance angiography (WH-MRA) is useful noninvasive examination. Its signal acquisition is performed during very short still timing in each cardiac motion cycle, andExpand
[Chemotherapy using gemcitabine hydrochloride for malignant lymphoma].
This report summarizes the use of gemcitabine for the treatment of malignant lymphoma. Gemcitabine is a deoxycytidine antagonist that has characteristics different from those of the deoxycytidineExpand
[Development of an automated processing method to detect coronary motion for coronary magnetic resonance angiography].
PURPOSE On coronary MR angiography (CMRA), cardiac motions worsen the image quality. To improve the image quality, detection of cardiac especially for individual coronary motion is very important.Expand