Hirotsugu Kato

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To identify the novel inhibitor of de novo lipogenesis in hepatocytes, we screened for inhibitory activity of triglyceride (TG) synthesis using [14C]acetate in the human hepatoma cell line, HepG2. Using this assay system we discovered the novel compound, benzofuranyl alpha-pyrone (TEI-B00422). TEI-B00422 also inhibited the incorporation of acetate into the(More)
OBJECTIVE This study was designed to examine the effect of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) ligands on the inflammatory changes induced by the interaction between adipocytes and macrophages in obese adipose tissue. METHODS AND PROCEDURES PPAR-alpha ligands (Wy-14,643 and fenofibrate) were added to 3T3-L1 adipocytes, RAW264(More)
Glucokinase (GK) plays a critical role for maintaining glucose homeostasis with regulating glucose uptake in liver and insulin secretion in pancreas. GK activators have been reported to decrease blood glucose levels in patients with type 2 diabetes mellitus. However, clinical development of GK activators has failed due to the loss of glucose-lowering(More)
Caffeine, at doses which enhance killing by UV light, inhibits the biosynthesis of pyrimidines in Chinese hamster ovary cells (K1) in culture. This inhibition was measured as a decrease in [14C]UTP and [14C]CTP accumulation after a 3-h incubation with [14C]aspartate or [14C]orotate and a similar decrease in Urd-A cells (which lack the first three enzymes of(More)
Zymosan, the cell wall of Saccharomyces cerevisiae, induces innate immune responses involving prostanoid production and complement activation. However, the roles of prostanoids in zymosan-induced inflammation and their interaction with the complement system remain to be determined. To clarify these issues, we examined zymosan-induced pleurisy in mice(More)
This paper proposes an instruction method of brush strokes utilizing haptic devices. Focusing attention to the magnitude difference between the horizontal and the vertical in brush strokes, we introduced a position/force hybrid scheme for determining traction forces to be fed back to users: the horizontal component of the force was given to reduce the(More)
The function of synapsin I is regulated by phosphorylation of the molecule at multiple sites; among them, the Ser(603) residue (site 3) is considered to be a pivotal site targeted by Ca(2+)/calmodulin-dependent kinase II (CaMKII). Although phosphorylation of the Ser(603) residue responds to several kinds of stimuli, it is unlikely that many or all of the(More)
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