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ORMDL3 on chromosome 17q21 is highly linked to asthma and regulates several downstream pathways including ATF6α. We demonstrated that ATF6α in airway smooth muscle (ASM) plays an important role in ASM contractility, proliferation, and AHR.
BACKGROUND Airway hyperresponsiveness is a major feature of asthma attributed predominantly to an extrinsic immune/inflammatory response increasing airway smooth muscle (ASM) contractility. OBJECTIVE We investigated whether increased ASM expression of orosomucoid-like 3 (ORMDL3), a gene on chromosome 17q21 highly linked to asthma, induced increased ASM… (More)