Hirotoshi Nakamura

Publications213
h-index37
Citations4,780
Highly Influential Citations161
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Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' disease.
TLDR
MMI 15 mg/d is suitable for mild and moderate GD, whereas MMI 30 mg/D is advisable for severe cases, and PTU is not recommended for initial use.
Acute exacerbation of interstitial pneumonia associated with collagen vascular diseases
TLDR
It is suggested that AE can occur in CVD-IP, and this condition is closely similar to that of IPF with poor prognosis.
Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages.
TLDR
Data indicate that PPARgamma expressed by AMs play an antiinflammatory role through inhibiting cytokine production and increasing their CD36 expression together with the enhanced phagocytosis of apoptotic neutrophils, which is an essential process for the resolution of inflammation.
Analysis of 754 cases of antithyroid drug-induced agranulocytosis over 30 years in Japan.
TLDR
Agranulocytosis tends to occur abruptly within 3 months after initiation of ATD therapy, although it develops gradually in some patients, and providing every patient with sufficient information on agranulocyTosis is critical.
Mouse lung CD103+ and CD11bhigh dendritic cells preferentially induce distinct CD4+ T-cell responses.
TLDR
The data suggest that mouse CD103(+) LDCs predominantly elicit Th1 and Th17 responses, whereas CD11b(high) L DCs primarily provoke a Th2 response under the steady state.
Immunohistochemistry of IgG4 can help subclassify Hashimoto's autoimmune thyroiditis
TLDR
Investigation of the infiltration of IgG‐ and IgG4‐positive plasma cells on immunohistochemistry for a panel of thyroiditis samples found that immunostaining of Ig g4 can help subclassify Hashimoto's thyroiditis; and Igg4 thyroiditis may have a close relationship with IgG 4‐related sclerosing disease.
Differences in clinical features and prognosis of interstitial lung diseases between polymyositis and dermatomyositis.
TLDR
DM-ILD is more refractory to corticosteroid therapy, resulting in poorer prognosis compared with PM-ILD, and data indicate that intensive therapy, including cyclosporine, should be considered for DM-ILD.
Higher sensitivity and specificity for diffusion-weighted imaging of malignant lung lesions without apparent diffusion coefficient quantification.
TLDR
LSR measurement on high-b value DW imaging may be useful for differentiating between benign and malignant lung nodules, while there were no significant differences between them in relation to ADC.
Successful interferon therapy reverses enhanced hepatic iron accumulation and lipid peroxidation in chronic hepatitis C
TLDR
Patients with CH-C have evidence of enhanced hepatic iron accumulation and lipid peroxidation compared to those with chronic hepatitis B, and inCH-C, hepatic siderosis and lipidPeroxidation are improved with successful IFN treatment, suggesting that hepatic lipid per oxidation and iron may potentially play contributory roles in the pathogenesis of CH- C.
1,25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor.
TLDR
D3 and its receptor (VDR) inhibited the transactivation of all four reporter constructs that are enhanced by CDCA/FXR and revealed that its ligand-bindingdomain (LBD) is responsible for the repression and the DNA-binding domain (DBD) is dispensable.
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