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Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' disease.
MMI 15 mg/d is suitable for mild and moderate GD, whereas MMI 30 mg/D is advisable for severe cases, and PTU is not recommended for initial use.
Analysis of 754 cases of antithyroid drug-induced agranulocytosis over 30 years in Japan.
Agranulocytosis tends to occur abruptly within 3 months after initiation of ATD therapy, although it develops gradually in some patients, and providing every patient with sufficient information on agranulocyTosis is critical.
Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages.
Data indicate that PPARgamma expressed by AMs play an antiinflammatory role through inhibiting cytokine production and increasing their CD36 expression together with the enhanced phagocytosis of apoptotic neutrophils, which is an essential process for the resolution of inflammation.
Mouse lung CD103+ and CD11bhigh dendritic cells preferentially induce distinct CD4+ T-cell responses.
The data suggest that mouse CD103(+) LDCs predominantly elicit Th1 and Th17 responses, whereas CD11b(high) L DCs primarily provoke a Th2 response under the steady state.
Differences in clinical features and prognosis of interstitial lung diseases between polymyositis and dermatomyositis.
DM-ILD is more refractory to corticosteroid therapy, resulting in poorer prognosis compared with PM-ILD, and data indicate that intensive therapy, including cyclosporine, should be considered for DM-ILD.
Immunohistochemistry of IgG4 can help subclassify Hashimoto's autoimmune thyroiditis
Investigation of the infiltration of IgG‐ and IgG4‐positive plasma cells on immunohistochemistry for a panel of thyroiditis samples found that immunostaining of Ig g4 can help subclassify Hashimoto's thyroiditis; and Igg4 thyroiditis may have a close relationship with IgG 4‐related sclerosing disease.
Higher sensitivity and specificity for diffusion-weighted imaging of malignant lung lesions without apparent diffusion coefficient quantification.
LSR measurement on high-b value DW imaging may be useful for differentiating between benign and malignant lung nodules, while there were no significant differences between them in relation to ADC.
Plasma CCN2 (connective tissue growth factor; CTGF) is a potential biomarker in idiopathic pulmonary fibrosis (IPF).
1,25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor.
D3 and its receptor (VDR) inhibited the transactivation of all four reporter constructs that are enhanced by CDCA/FXR and revealed that its ligand-bindingdomain (LBD) is responsible for the repression and the DNA-binding domain (DBD) is dispensable.