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Stereocontrolled synthesis of (+)-methoxyphenylkainic acid and (+)-phenylkainic acid.
TLDR
Complete stereoselective construction of the kainoid skeleton was accomplished by utilizing the stereochemistry at the C-4 position as a pivotal stereogenic center.
Practical synthesis of kainoids: a new chemical probe precursor and a fluorescent probe.
A practical total synthesis of kainoid MFPA (5) was achieved in only six steps, via a novel Ni-catalyst-mediated asymmetric conjugate addition reaction. Furthermore, a fluorescein-based fluorescent