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Superoxide Generation in Directional Coronary Atherectomy Specimens of Patients With Angina Pectoris
ROS were closely associated with the distribution of p22phox and oxidized LDL and the generation of superoxide in DCA specimens was assessed by the dihydroethidium method and lucigenin-enhanced chemiluminescence.
Interaction of Oxidative Stress and Inflammatory Response in Coronary Plaque Instability
Characteristics of histological plaque instability and higher levels of serum CRP and fibrinogen were associated with the CRP immunoreactivity and the expression of CRP mRNA and protein was detected in cultured human coronary artery smooth muscle cells.
Endothelial NO Synthase Overexpression Inhibits Lesion Formation in Mouse Model of Vascular Remodeling
In this vascular remodeling model, the endothelium remains uninjured, but neointimal and medial thickening occurs in combination with a reduction in vascular diameter at the proximal portion of the ligation.
Expression of NADH/NADPH Oxidase p22phox in Human Coronary Arteries
The aim of this study was to investigate the localization of p22phox in human coronary arteries and to examine its difference in expression between nonatherosclerosis and atherosclerotic coronary arteries.
Expression of Glutaredoxin in Human Coronary Arteries
In nonatherosclerotic coronary arteries, glutaredoxin was expressed in endothelial cells, in fibroblasts of the adventitia, and most intensely in medial smooth muscle cells, Interestingly, in atherosclerosis lesions such as hypercellular lesions, the infiltrating macrophages highly expressed glutared toxin.
Impact of NAD(P)H Oxidase-Derived Reactive Oxygen Species on Coronary Arterial Remodeling
The relationship between coronary arterial remodeling and ROS generation was examined by comparing preinterventional intravascular ultrasound findings of atherosclerotic lesions to the histochemical findings of corresponding specimens obtained by directional coronary atherectomy.