Hiroshi Yamaura

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Dopaminergic systems have been known to be involved in the regulation of locomotor activity and development of psychosis. However, the observations that some Parkinson’s disease patients can move effectively under appropriate conditions despite low dopamine levels (eg, kinesia paradoxia) and that several psychotic symptoms are typical antipsychotic(More)
Anabaena sp. strain PCC 7120 is a filamentous cyanobacterium that differentiates nitrogen-fixing heterocysts when fixed nitrogen becomes growth limiting in the medium. The gene alr2338 (designated fraG herein), located immediately upstream of the master regulator of differentiation hetR, was identified in a genetic screen for mutants unable to grow(More)
Obstacle avoidance during locomotion is essential for safe, smooth locomotion. Physiological studies regarding muscle synergy have shown that the combination of a small number of basic patterns produces the large part of muscle activities during locomotion and the addition of another pattern explains muscle activities for obstacle avoidance. Furthermore,(More)
We have developed a hand rehabilitation system for patients suffering from paralysis or contracture. It consists of two components: a hand rehabilitation machine, which moves human finger joints with motors, and a data glove, which provides control of the movement of finger joints attached to the rehabilitation machine. The machine is based on the arm(More)
In this paper, we present a hand rehabilitation system for patients suffering from paralysis or contracture. It consist of two components: a hand rehabilitation machine, which moves human finger joints using motors, and a data glove, which enables controlling the movement of the finger joints attached to the rehabilitation machine. The machine is based on(More)
Phosphorodiamidate morpholino oligonucleotide (PMO)-mediated control of the alternative splicing of the chloride channel 1 (CLCN1) gene is a promising treatment for myotonic dystrophy type 1 (DM1) because the abnormal splicing of this gene causes myotonia in patients with DM1. In this study, we optimised a PMO sequence to correct Clcn1 alternative splicing(More)
This paper presents the development of the mathematical model and controller of a light weight and small size robot finger. The finger possesses self adaptive grasping capability and is made of seven bar linkages with a slider or lead screw mechanism in the middle phalanx to adjust its effective length in realizing both pinching and grasping tasks. The(More)
This paper presents a new Feedback Error Learning (FEL) scheme with the application of Radial Basis Function Network (RBFN) based Finite Impulse Response (FIR) filter to control underactuated systems. This method provides a stable feedback controller which is systematically derived from sequential backstepping control procedure. Besides, it also formulates(More)
This study developed a musculoskeletal model of the hind legs of the rat. The skeletal model consists of planar seven rigid links that represent the trunk and the hind legs. The front legs are fixed on the trunk and slide on the ground without friction. The muscle model has seven principal muscles for each hind leg. The physical parameters of the(More)
We investigated the obstacle avoidance in locomotion of the rat using a neuromusculoskeletal model. We constructed a musculoskeletal model of the hindlimbs based on the measured anatomical data and constructed a nervous system model based on the central pattern generator and muscle synergy. We incorporated sensory regulation models based on interlimb(More)