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2018
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- Marc Mesnil, Hiroshi Yamasaki
- Cancer research
- 2000
Antitumor suicide gene therapy is one of the emerging strategies against cancer. It consists of the introduction into cancer cells of a gene capable of converting a nontoxic prodrug into a cytotoxic… (More)
- Hiroshi Yamasaki, Vladimir A Krutovskikh, Marc Mesnil, Torao Tanaka, Maria-Lucia Zaidan-Dagli, Yasufumi Omori
- Comptes rendus de l'Academie des sciences. Serie…
- 1999
Gap junctional intercellular communication (GJIC) is considered to play a key role in the maintenance of tissue independence and homeostasis in multicellular organisms by controlling the growth of… (More)
- Hiroshi Yamasaki
- Carcinogenesis
- 1990
- Vladimir A Krutovskikh, Guido Mazzoleni, +6 authors Hiroshi Yamasaki
- International journal of cancer
- 1994
Gap-junctional intercellular communication (GJIC) in 20 primary human liver tumors with different degrees of malignancy has been studied at the functional and molecular levels. When GJIC capacity was… (More)
- Agnès Duflot-Dancer, Marc Mesnil, Hiroshi Yamasaki
- Oncogene
- 1997
Connexin genes exert negative growth control when transfected into various types of tumor cell lines. We previously demonstrated that connexin 26 (Cx26) suppresses in vitro and in vivo growth of HeLa… (More)
- Marc Mesnil, Colette Piccoli, G. Tiraby, Klaus Willecke, Hiroshi Yamasaki
- Proceedings of the National Academy of Sciences…
- 1996
In gene therapy to treat cancer, typically only a fraction of the tumor cells can be successfully transfected with a gene. However, in the case of brain tumor therapy with the thymidine kinase gene… (More)
- Marc Mesnil, Vladimir A Krutovskikh, +4 authors Hiroshi Yamasaki
- Cancer research
- 1995
In order to examine whether different connexin gene species exert different degrees of tumor-suppressing activity, we characterized growth characteristics of a gap junction-deficient human cancer… (More)
- Yasufumi Omori, Hiroshi Yamasaki
- International journal of cancer
- 1998
Many lines of evidence support the hypothesis that connexins form a family of tumor-suppressor genes. Transfection of connexin43 (Cx43) into rat C6 glioma cells have revealed that Cx43 functions as a… (More)
- Vladimir A Krutovskikh, Marc Mesnil, Guido Mazzoleni, Hiroshi Yamasaki
- Laboratory investigation; a journal of technical…
- 1995
BACKGROUND
Gap junctional intercellular communication is believed to play an important role in the maintenance of tissue homeostasis, and disruption of it has been proposed to be involved in… (More)
- Tomohiro Yano, Francisco Javier Hernandez-Blazquez, Yasufumi Omori, Hiroshi Yamasaki
- Carcinogenesis
- 2001
Connexin (Cx) genes have a negative growth effect on tumour cells with certain specificity. However, it is not clear whether each Cx gene can act similarly in growth control. Hepatocytes normally… (More)