Hiroshi Watanabe

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Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal inherited arrhythmia syndrome in which drug therapy is often ineffective. We discovered that flecainide prevents arrhythmias in a mouse model of CPVT by inhibiting cardiac ryanodine receptor-mediated Ca(2+) release and thereby directly targeting the underlying molecular(More)
This study aimed to clarify the size and morphology of the mandible, and to identify the location of the mandibular canal for the planning of the dental implantation. CT data of 79 Japanese patients (52 male and 27 female) were analyzed. The means of the height and width ranged from 27.6 to 31.0 mm and from 10.5 to 15.8 mm, respectively. The height in male(More)
The extraordinary radiation resistance of Deinococcus radiodurans results from the efficient capacity of the bacterium to repair DNA double-strand breaks. By analysing the DNA damage repair-deficient mutant, KH311, a unique radiation-inducible gene (designated pprA) responsible for loss of radiation resistance was identified. Investigations in vitro showed(More)
RATIONALE Voltage-gated sodium channels initiate action potentials in excitable tissues. Mice in which Scn5A (the predominant sodium channel gene in heart) has been knocked out die early in development with cardiac malformations by mechanisms which have yet to be determined. OBJECTIVE Here we addressed this question by investigating the role of cardiac(More)
Darunavir (DRV) is a nonpeptidic protease inhibitor (PI) approved for the treatment of human immunodeficiency virus (HIV) infection. DRV displays potent activity against HIV strains resistant to other available PIs. Coadministration with ritonavir (RTV) improves the oral bioavailability of DRV. Inhibition of cytochrome P450 by RTV has been proposed as a(More)
9 We use the concept of a distributive law of a monad over a copointed endofunctor to define and develop a reformulation andmild generalisation of Turi and Plotkin’s notion of an abstract operational 11 rule. We make our abstract definition and give a precise analysis of the relationship between it and Turi and Plotkin’s definition. Following Turi and(More)
Interferon (IFN) is expected to prevent the progression of hepatitis C virus infection to cirrhosis and the development of hepatocellular carcinoma (HCC), but there have been several reports of the development of HCC after a sustained response to IFN. Our aim was to elucidate the incidence and clinical features of, and risk factors for, HCC in sustained(More)
Recombinant wild-type human serum albumin (rHSA), the single-residue mutants K199A, K439A and K525A and the triple-residue mutant K199A/K439A/K525A were produced using a yeast expression system. Portions of the rHSA were glycated to different degrees (2.5-250 mM D-glucose). As detected by far-UV and near-UV CD, intrinsic tryptophan-fluorescence and probed(More)
BACKGROUND Dyslipidemia, an important risk factor for cardiovascular disease, may be associated with atrial fibrillation (AF). Cross-sectional studies that have examined this association, however, have produced controversial results, and few longitudinal studies have been conducted. METHODS AND RESULTS Using annual health examinations in Japan, the(More)
Hiroshi Watanabe, MD, PhD, FESC; Akihiko Nogami, MD, PhD; Kimie Ohkubo, MD, PhD; Hiro Kawata, MD, PhD; Yuka Hayashi, MD; Taisuke Ishikawa, DVM; Takeru Makiyama, MD, PhD; Satomi Nagao, MD; Nobue Yagihara, MD; Naofumi Takehara, MD, PhD; Yuichiro Kawamura, MD, PhD; Akinori Sato, MD, PhD; Kazuki Okamura, MD, PhD; Yukio Hosaka, MD, PhD; Masahito Sato, MD, PhD;(More)