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Retinal Pigment Epithelium-Derived CTLA-2α Induces TGFβ-Producing T Regulatory Cells12
T cells that encounter ocular pigment epithelium in vitro are inhibited from undergoing TCR-triggered activation, and instead acquire the capacity to suppress the activation of bystander T cells.Expand
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Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals.
The majority of maturing T lymphocytes that recognize self-antigens is eliminated in the thymus upon exposure to their target antigens. This physiological process of negative selection requires thatExpand
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Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells.
T cells that encounter ocular pigment epithelium in vitro are inhibited from undergoing TCR-triggered activation, and instead acquire the capacity to suppress the activation of bystander T cells.Expand
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Role of Thrombospondin-1 in T Cell Response to Ocular Pigment Epithelial Cells12
Ocular pigment epithelium (PE) cells promote the generation of T regulators (PE-induced Treg cells). Moreover, T cells exposed to PE acquire the capacity to suppress the activation of bystander TExpand
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Acquisition of T Regulatory Function in Cathepsin L-Inhibited T Cells by Eye-Derived CTLA-2α during Inflammatory Conditions1
Pigment epithelium isolated from the eye possesses immunosuppressive properties such as regulatory T (Treg) cell induction; e.g., cultured retinal pigment epithelium (RPE) converts CD4+ T cells intoExpand
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Suppression of interleukin-17-producing T-helper 17 cells by retinal pigment epithelial cells
PurposeTo determine whether retinal pigment epithelial (RPE) cells can inhibit cytokine production by activated T helper (Th) cells.MethodsPrimary RPE cells were cultured from normal C57BL/6 mice.Expand
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Inflammatory processes triggered by TCR engagement or by local cytokine expression: differences in profiles of gene expression and infiltrating cell populations
Immune cell‐mediated inflammatory responses are triggered by TCR engagement with the target antigen, the initial event that brings about the complex sequence of events of the inflammatory process.Expand
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Hainosan (painongsan) suppresses the biofilm formation of Porphyromonas gingivalis and Prevotella intermedia in vitro
Porphyromonas gingivalis and Prevotella intermedia are pathogenic bacteria that cause several periodontal diseases such as periodontitis. They frequently form biofilm to protect from threats such asExpand
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