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RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β
TLDR
This study shows that RANKL induces the interferon-β (IFN- β) gene in osteoclast precursor cells, and that IFN-β inhibits the differentiation by interfering with the RankL-induced expression of c-Fos, an essential transcription factor for the formation of osteoclasts. Expand
FUNCTIONAL ASSESSMENT OF ABCG2 (BCRP) GENE POLYMORPHISMS TO PROTEIN EXPRESSION IN HUMAN PLACENTA
TLDR
The results suggest that 1) the predominant allelic expression pattern of BCRP in placental samples is biallelic, and 2) the mutation C421A is not a genetic variant acting in cis, but is considered to influence the translation efficiency. Expand
Polymorphisms of OATP‐C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics
Objective: Our objective was to quantitate the contribution of the genetic polymorphisms of the genes for 2 human organic anion transporters—organic anion transporting polypeptide C (OATP‐C) andExpand
Transcellular Transport of Organic Anions Across a Double-transfected Madin-Darby Canine Kidney II Cell Monolayer Expressing Both Human Organic Anion-transporting Polypeptide (OATP2/SLC21A6) and
TLDR
A double-transfected Madin-Darby canine kidney (MDCK II) cell monolayer is established, which expresses both OATP2 and MRP2 on basal and apical membranes, respectively, and may be used to analyze the hepatic vectorial transport of organic anions and to screen the transport profiles of new drug candidates. Expand
ABCG2 Transports Sulfated Conjugates of Steroids and Xenobiotics*
TLDR
It was suggested that ABCG2 preferentially transports sulfate conjugates and that E1S and DHEAS are the potential physiological substrates for this transporter. Expand
Characterization of the Efflux Transport of 17β-Estradiol-d-17β-glucuronide from the Brain across the Blood-Brain Barrier
The contribution of organic anion transporters to the total efflux of 17beta-estradiol-D-17beta-glucuronide (E(2)17betaG) through the blood-brain barrier (BBB) was investigated using the Brain EffluxExpand
Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population
TLDR
In a Japanese population, another risk variant in ABCG2, namely the Q126X nonfunctional mutation, confers an even higher risk associated with an increase in uric acid deposition in the blood and may cause gout in Asians, lending weight to previously reported GWAS. Expand
Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts.
TLDR
It is demonstrated for the first time that Nrf2 is required for the constitutive and inducible expression of Mrp family proteins in mouse fibroblasts. Expand
Functional Analysis of SNPs Variants of BCRP/ABCG2
TLDR
The results suggest that Q141K SNPs may associate with a lower expression level, and S441NSNPs may affect both the expression level and cellular localization in breast cancer resistance protein. Expand
Comparative Studies on in Vitro Methods for Evaluating in Vivo Function of MDR1 P-Glycoprotein
TLDR
The extent of ATP-hydrolysis in vitro may also be a useful parameter for in vivo prediction, particularly for eliminating P-gp substrates in high-throughput screening procedures. Expand
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