RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β
This study shows that RANKL induces the interferon-β (IFN- β) gene in osteoclast precursor cells, and that IFN-β inhibits the differentiation by interfering with the RankL-induced expression of c-Fos, an essential transcription factor for the formation of osteoclasts.
Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3)*
- T. Hirohashi, Hiroshi Suzuki, Yuichi Sugiyama
- Biology, ChemistryThe Journal of Biological Chemistry
- 21 May 1999
It is demonstrated that several kinds of organic anions are transported via MRP3, although the substrate specificity of MRp3 differs from that of MRP1 and cMOAT/MRP2 in that glutathione conjugates are poor substrates for MRP 3.
ABCG2 Transports Sulfated Conjugates of Steroids and Xenobiotics*
- Michiko Suzuki, Hiroshi Suzuki, Y. Sugimoto, Y. Sugiyama
- Biology, ChemistryJournal of Biological Chemistry
- 20 June 2003
It was suggested that ABCG2 preferentially transports sulfate conjugates and that E1S and DHEAS are the potential physiological substrates for this transporter.
FUNCTIONAL ASSESSMENT OF ABCG2 (BCRP) GENE POLYMORPHISMS TO PROTEIN EXPRESSION IN HUMAN PLACENTA
The results suggest that 1) the predominant allelic expression pattern of BCRP in placental samples is biallelic, and 2) the mutation C421A is not a genetic variant acting in cis, but is considered to influence the translation efficiency.
Transcellular Transport of Organic Anions Across a Double-transfected Madin-Darby Canine Kidney II Cell Monolayer Expressing Both Human Organic Anion-transporting Polypeptide (OATP2/SLC21A6) and…
- M. Sasaki, Hiroshi Suzuki, Kousei Ito, T. Abe, Y. Sugiyama
- BiologyJournal of Biological Chemistry
- 22 February 2002
A double-transfected Madin-Darby canine kidney (MDCK II) cell monolayer is established, which expresses both OATP2 and MRP2 on basal and apical membranes, respectively, and may be used to analyze the hepatic vectorial transport of organic anions and to screen the transport profiles of new drug candidates.
Polymorphisms of OATP‐C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics
Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population
In a Japanese population, another risk variant in ABCG2, namely the Q126X nonfunctional mutation, confers an even higher risk associated with an increase in uric acid deposition in the blood and may cause gout in Asians, lending weight to previously reported GWAS.
Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts.
Comparative Studies on in Vitro Methods for Evaluating in Vivo Function of MDR1 P-Glycoprotein
The extent of ATP-hydrolysis in vitro may also be a useful parameter for in vivo prediction, particularly for eliminating P-gp substrates in high-throughput screening procedures.
Characterization of the Efflux Transport of 17β-Estradiol-d-17β-glucuronide from the Brain across the Blood-Brain Barrier
Taking the selectivity of these inhibitors into consideration, the maximum contribution made by the Oatp2 and Oat family to the total efflux of E(2)17betaG from the brain appears to be about 40 and 20%, respectively.