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- Masashi Tanaka, Vicente M Cabrera, +25 authors Hidetoshi Shimodaira
- Genome research
- 2004
To construct an East Asia mitochondrial DNA (mtDNA) phylogeny, we sequenced the complete mitochondrial genomes of 672 Japanese individuals (http://www.giib.or.jp/mtsnp/index_e.html). This allowed us… (More)
- Takao K Suzuki, Hiroyuki Shimada, +7 authors Takashi Kato
- PloS one
- 2013
BACKGROUND
To examine the effect of multicomponent exercise program on memory function in older adults with mild cognitive impairment (MCI), and identify biomarkers associated with improvement of… (More)
- Michael V Holmes, Paul J. Newcombe, +43 authors Juan P. Casas
- The Lancet
- 2011
BACKGROUND
The MTHFR 677C→T polymorphism has been associated with raised homocysteine concentration and increased risk of stroke. A previous overview showed that the effects were greatest in regions… (More)
- Hideki Nomura, Hiroshi Shimokata, Fujiko Ando, Yozo Miyake, Fumio Kuzuya
- Ophthalmology
- 1999
OBJECTIVE
To assess the influence of aging, blood pressure, and body mass index (BMI) on intraocular pressure (IOP) in a large Japanese population.
DESIGN
Cross-sectional and longitudinal study.
… (More)
- Hideki Nomura, Fujiko Ando, Naoakira Niino, Hiroshi Shimokata, Yozo Miyake
- Current eye research
- 2002
PURPOSE
Previous cross-sectional Japanese studies have shown that intraocular pressure (IOP) decreases with age. However, central corneal thickness (CCT) variation should also be considered when… (More)
- Hiroshi Shimokata, Denis C. Muller, Reubin Andres
- JAMA
- 1989
Cross-sectional associations between smoking habits, body mass index, and waist-hip ratio (WHR) were examined in 1122 men aged 19 to 102 years. Weight and body mass index were significantly lower in… (More)
- Yoshiji Yamada, Fujiko Ando, Naoakira Niino, Hiroshi Shimokata
- Molecular genetics and metabolism
- 2003
Given that osteoprotegerin plays an important role in bone remodeling, the osteoprotegerin gene may be a candidate locus for susceptibility to osteoporosis. The relation of polymorphisms in the… (More)
- Naoko Shimizu, Hideki Nomura, Fujiko Ando, Naoakira Niino, Yozo Miyake, Hiroshi Shimokata
- Japanese journal of ophthalmology
- 2003
PURPOSE
To investigate the refractive status and factors associated with myopia by a population-based survey of Japanese adults.
METHODS
A total of 2168 subjects aged 40 to 79 years, randomly… (More)
- Yoshiji Yamada, Fujiko Ando, Naoakira Niino, Shigeo Ohta, Hiroshi Shimokata
- Journal of Molecular Medicine
- 2002
The estrogen receptor α gene is a candidate locus for genetic influence on bone mass. The possible association between two polymorphisms in the first intron of this gene, alone or in combination, and… (More)
- Hiroshi Shimokata, Jordan D. Tobin, Denis C. Muller, Dariush H Elahi, Patricia J. Coon, Reubin Andres
- Journal of gerontology
- 1989
The pattern of body fat distribution has been shown to be related to a large number of variables of clinical importance. A variety of indices have been devised, many of them simple enough to be… (More)